ArticleProceedings of the National Academy of Sciences of the United States of America2016
Circadian rhythms identified in Caenorhabditis elegans by in vivo long-term monitoring of a bioluminescent reporter.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Circadian-shaped immune variability predicts infection outcome.Science advances · 2026Article
- HY5 integrates light and electrical signaling to trigger a jasmonate burst for nematode defense in tomato.Nature communications · 2025Article
- A wrinkle in timers: evolutionary rewiring of conserved biological timekeepers.Trends in biochemical sciences · 2025Review
- Role of the clock gene homologFrontiers in neuroscience · 2025Article
- Rhythms in lipid droplet content driven by a metabolic oscillator are conserved throughout evolution.Cellular and molecular life sciences : CMLS · 2024Article
- Clock gene homologs lin-42 and kin-20 regulate circadian rhythms in C. elegans.Scientific reports · 2024Article
- Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans.Communications biology · 2024Article
- NanoBRET in C. elegans illuminates functional receptor interactions in real time.BMC molecular and cell biology · 2022Article
- Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish.Frontiers in nutrition · 2022Article
- Neural and behavioral control inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- In Vivo Simultaneous Analysis of Gene Expression by Dual-Color Luciferases inInternational journal of molecular sciences · 2020Article
- Methylation deficiency disrupts biological rhythms from bacteria to humans.Communications biology · 2020Article
- Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms.Nutrients · 2020Review
- Social Chemical Communication Determines Recovery From L1 Arrest via DAF-16 Activation.Frontiers in cell and developmental biology · 2020Article
- Root-knot nematodes demonstrate temporal variation in host penetration.Journal of nematology · 2020Article
- Simultaneous multi-signal quantification for highly precise serodiagnosis utilizing a rationally constructed platform.Nature communications · 2019Article
- AMP-Activated Protein Kinase Regulates Circadian Rhythm by Affecting CLOCK inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging.Nutrients · 2019Review
- The Complex Interplay of Parasites, Their Hosts, and Circadian Clocks.Frontiers in cellular and infection microbiology · 2019Review
- Caenorhabditis elegans and its applicability to studies on restless legs syndrome.Advances in pharmacology (San Diego, Calif.) · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Circadian rhythms are based on endogenous clocks that allow organisms to adjust their physiology and behavior by entrainment to the solar day and, in turn, to select the optimal times for most biological variables. Diverse model systems-including mice, flies, fungi, plants, and bacteria-have provided important insights into the mechanisms of circadian rhythmicity. However, the general principles that govern the circadian clock of Caenorhabditis elegans have remained largely elusive. Here we report robust molecular circadian rhythms in C elegans recorded with a bioluminescence assay in vivo and demonstrate the main features of the circadian system of the nematode. By constructing a luciferase-based reporter coupled to the promoter of the suppressor of activated let-60 Ras (sur-5) gene, we show in both population and single-nematode assays that C elegans expresses ∼24-h rhythms that can be entrained by light/dark and temperature cycles. We provide evidence that these rhythms are temperature-compensated and can be re-entrained after phase changes of the synchronizing agents. In addition, we demonstrate that light and temperature sensing requires the photoreceptors LITE and GUR-3, and the cyclic nucleotide-gated channel subunit TAX-2. Our results shed light on C elegans circadian biology and demonstrate evolutionarily conserved features in the circadian system of the nematode.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.