Evidence map›Paper›PMID 27849610›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure.

Ying-Chih Lin, Nichole Owen, Irina G Minko, Sabine S Lange, Junya Tomida, Liang Li, Michael P Stone, Richard D Wood, Amanda K McCullough, R Stephen Lloyd

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The aflatoxin BNAR cancer · 2025
    Article
  6. Frequencies and spectra of aflatoxin BNAR molecular medicine · 2024
    Article
  7. The aflatoxin BEnvironmental and molecular mutagenesis · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Risk assessment of aflatoxins in food.EFSA journal. European Food Safety Authority · 2020
    Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. CYP1B1 converts procarcinogens into genotoxins in Saccharomyces cerevisiae.Mutation research. Genetic toxicology and environmental mutagenesis
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ying-Chih LinCancer Biology Program, Oregon Health & Science University, Portland, OR 97239.
Nichole OwenOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
Irina G MinkoOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
Sabine S LangeDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957.
Junya Tomida
Liang LiDepartment of Chemistry, Vanderbilt University, Nashville, TN 37235.
Michael P StoneDepartment of Chemistry, Vanderbilt University, Nashville, TN 37235.
Richard D WoodDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957.
Amanda K McCulloughOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.
R Stephen LloydOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239; lloydst@ohsu.edu.
Oregon Health & Science University · USThe University of Texas MD Anderson Cancer Center · USVanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Structural Biology Facility CoreP30ES000267 · NIEHS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 1985 to 2014
$20.3M
DNA Adduct-Induced MutagenesisR01CA055678 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 1992 to 2016
$4.0M
Function of REV3L in limiting oncogenesis via DNA damage toleranceR01CA132840 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WOOD, RICHARD D · 2009 to 2013
$1.6M
NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA055678NCI NIH HHS R01 CA132840NIEHS NIH HHS P30 ES000267
6 · The paper itself

Abstract

Routine dietary consumption of foods that contain aflatoxins is the second leading cause of environmental carcinogenesis worldwide. Aflatoxin-driven mutagenesis is initiated through metabolic activation of aflatoxin B

Indexed as

Aflatoxin B1AflatoxinsAnimalsCarcinoma, HepatocellularCell SurvivalChromosome AberrationsCytidineDNA AdductsDNA-Binding ProteinsDNA DamageDNA-Directed DNA PolymeraseDNA RepairFibroblastsHumansLiver NeoplasmsMice8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxyaflatoxin B1Aflatoxin B1AflatoxinsCytidineDNA AdductsDNA-Binding ProteinsDNA-Directed DNA PolymeraseDNA polymerase zetaREV3L protein, humanREV3L protein, mouseaflatoxinenvironmental toxinshepatocellular carcinogenesismutagenesistranslesion DNA synthesis

Identifiers

PMID27849610
PMCPMC5137696
OpenAlexW2550851628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.