ArticleProceedings of the National Academy of Sciences of the United States of America2016
Standing genetic variation in a tissue-specific enhancer underlies selfing-syndrome evolution in Capsella.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Linking genomic variation to floral trait adaptation across species boundaries.The New phytologist · 2026Review
- Profiling the epigenomic landscape of late embryonic and adult mouse hind limb muscles.Scientific reports · 2026Article
- Characteristics of Floral Volatiles and Their Effects on Attracting Pollinating Insects in ThreeBiology · 2025Article
- Natural Variation in Sexual Traits and Gene Expression between Selfing and Outcrossing Arabidopsis lyrata Suggests Sexual Selection at Work.Plant & cell physiology · 2025Article
- Altered interactions between cis-regulatory elements partially resolve BLADE-ON-PETIOLE genetic redundancy in Capsella rubella.The Plant cell · 2024Article
- Foraging bee species differentially prioritize quantity and quality of floral rewards.PNAS nexus · 2024Article
- Genetic and demographic signatures accompanying the evolution of the selfing syndrome in Daphne kiusiana, an evergreen shrub.Annals of botany · 2023Article
- Natural variation of GhSI7 increases seed index in cotton.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- The selfing syndrome and beyond: diverse evolutionary consequences of mating system transitions in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- SlKIX8 and SlKIX9 are negative regulators of leaf and fruit growth in tomato.Plant physiology · 2022Article
- Genomic editing of intronic enhancers unveils their role in fine-tuning tissue-specific gene expression in Arabidopsis thaliana.The Plant cell · 2021Article
- Review
- Article
- The SAP function in pistil development was proved by two allelic mutations in Chinese cabbage (Brassica rapa L. ssp. pekinensis).BMC plant biology · 2020Article
- Fine-Mapping of a Wild Genomic Region Involved in Pod and Seed Size Reduction on Chromosome A07 in Peanut (Genes · 2020Article
- HEARTBREAK Controls Post-translational Modification of INDEHISCENT to Regulate Fruit Morphology in Capsella.Current biology : CB · 2020Article
- SMALL LEAF AND BUSHY1 controls organ size and lateral branching by modulating the stability of BIG SEEDS1 in Medicago truncatula.The New phytologist · 2020Article
- A Similar Genetic Architecture Underlies the Convergent Evolution of the Selfing Syndrome inThe Plant cell · 2020Article
- Influence of genetic polymorphism on transcriptional enhancer activity in the malaria vector Anopheles coluzzii.Scientific reports · 2019Article
- Reproductive assurance weakens pollinator-mediated selection on flower size in an annual mixed-mating species.Annals of botany · 2019Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Mating system shifts recurrently drive specific changes in organ dimensions. The shift in mating system from out-breeding to selfing is one of the most frequent evolutionary transitions in flowering plants and is often associated with an organ-specific reduction in flower size. However, the evolutionary paths along which polygenic traits, such as size, evolve are poorly understood. In particular, it is unclear how natural selection can specifically modulate the size of one organ despite the pleiotropic action of most known growth regulators. Here, we demonstrate that allelic variation in the intron of a general growth regulator contributed to the specific reduction of petal size after the transition to selfing in the genus Capsella Variation within this intron affects an organ-specific enhancer that regulates the level of STERILE APETALA (SAP) protein in the developing petals. The resulting decrease in SAP activity leads to a shortening of the cell proliferation period and reduced number of petal cells. The absence of private polymorphisms at the causal region in the selfing species suggests that the small-petal allele was captured from standing genetic variation in the ancestral out-crossing population. Petal-size variation in the current out-crossing population indicates that several small-effect mutations have contributed to reduce petal-size. These data demonstrate how tissue-specific regulatory elements in pleiotropic genes contribute to organ-specific evolution. In addition, they provide a plausible evolutionary explanation for the rapid evolution of flower size after the out-breeding-to-selfing transition based on additive effects of segregating alleles.
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