Evidence map›Paper›PMID 27849220›Full record

ArticleMemorias do Instituto Oswaldo Cruz2016

Surveillance of antiviral resistance markers in Argentina: detection of E119V neuraminidase mutation in a post-treatment immunocompromised patient.

Andrea Pontoriero, Martín Avaro, Estefania Benedetti, Mara Russo, Andrea Czech, Natalia Periolo, Ana Campos, Ana Zamora, Elsa Baumeister

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Memorias do Instituto Oswaldo Cruz, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Andrea PontorieroNational Influenza Centre PAHO/WHO, National Reference Laboratory, Respiratory Viral Diseases Service, Department of Virology, National Institute of Infectious Diseases, National Agency of Laboratories and Institutes of Health Dr Carlos G Malbrán, Ciudad de Buenos Aires, Buenos Aires, Argentina.
Martín AvaroNational Influenza Centre PAHO/WHO, National Reference Laboratory, Respiratory Viral Diseases Service, Department of Virology, National Institute of Infectious Diseases, National Agency of Laboratories and Institutes of Health Dr Carlos G Malbrán, Ciudad de Buenos Aires, Buenos Aires, Argentina.
Estefania BenedettiNational Influenza Centre PAHO/WHO, National Reference Laboratory, Respiratory Viral Diseases Service, Department of Virology, National Institute of Infectious Diseases, National Agency of Laboratories and Institutes of Health Dr Carlos G Malbrán, Ciudad de Buenos Aires, Buenos Aires, Argentina.
Mara RussoNational Influenza Centre PAHO/WHO, National Reference Laboratory, Respiratory Viral Diseases Service, Department of Virology, National Institute of Infectious Diseases, National Agency of Laboratories and Institutes of Health Dr Carlos G Malbrán, Ciudad de Buenos Aires, Buenos Aires, Argentina.
Andrea CzechNational Influenza Centre PAHO/WHO, National Reference Laboratory, Respiratory Viral Diseases Service, Department of Virology, National Institute of Infectious Diseases, National Agency of Laboratories and Institutes of Health Dr Carlos G Malbrán, Ciudad de Buenos Aires, Buenos Aires, Argentina.
Natalia PerioloNational Influenza Centre PAHO/WHO, National Reference Laboratory, Respiratory Viral Diseases Service, Department of Virology, National Institute of Infectious Diseases, National Agency of Laboratories and Institutes of Health Dr Carlos G Malbrán, Ciudad de Buenos Aires, Buenos Aires, Argentina.
Ana CamposNational Influenza Centre PAHO/WHO, National Reference Laboratory, Respiratory Viral Diseases Service, Department of Virology, National Institute of Infectious Diseases, National Agency of Laboratories and Institutes of Health Dr Carlos G Malbrán, Ciudad de Buenos Aires, Buenos Aires, Argentina.
Ana ZamoraUniversity of Tucuman, School of Pharmacy and Biochemistry, Microbiology Institute, Tucuman, Argentina.
Elsa BaumeisterNational Influenza Centre PAHO/WHO, National Reference Laboratory, Respiratory Viral Diseases Service, Department of Virology, National Institute of Infectious Diseases, National Agency of Laboratories and Institutes of Health Dr Carlos G Malbrán, Ciudad de Buenos Aires, Buenos Aires, Argentina.
National Influenza Center · MNInstituto de Neurología Cognitiva · ARNational University of Tucumán · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although vaccines are the best means of protection against influenza, neuraminidase inhibitors are currently the main antiviral treatment available to control severe influenza cases. One of the most frequent substitutions in the neuraminidase (NA) protein of influenza A(H3N2) viruses during or soon after oseltamivir administration is E119V mutation. We describe the emergence of a mixed viral population with the E119E/V mutation in the NA protein sequence in a post-treatment influenza sample collected from an immunocompromised patient in Argentina. This substitution was identified by a real-time reverse transcriptase polymerase chain reaction (RT-PCR) protocol and was confirmed by direct Sanger sequencing of the original sample. In 2014, out of 1140 influenza samples received at the National Influenza Centre, 888 samples (78%) were A(H3N2) strains, 244 (21.3%) were type B strains, and 8 (0.7%) were A(H1N1)pdm09 strains. Out of 888 A(H3N2) samples, 842 were tested for the E119V substitution by quantitative RT-PCR: 841 A(H3N2) samples had the wild-type E119 genotype and in one sample, a mixture of viral E119/ V119 subpopulations was detected. Influenza virus surveillance and antiviral resistance studies can lead to better decisions in health policies and help in medical treatment planning, especially for severe cases and immunocompromised patients.

Indexed as

AdolescentAdultAgedAged, 80 and overAntiviral AgentsArgentinaChildChild, PreschoolFemaleHumansImmunocompromised HostInfantInfluenza A Virus, H3N2 SubtypeInfluenza, HumanMaleMiddle AgedAntiviral AgentsNA protein, influenza A virusNeuraminidaseOseltamivirViral Proteins

Identifiers

PMID27849220
PMCPMC5146738
OpenAlexW2554690634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.