Evidence map›Paper›PMID 27849181›Full record

ArticleInfection and immunity2017

NADPH Oxidase Contributes to Resistance against Aggregatibacter actinomycetemcomitans-Induced Periodontitis in Mice.

Antje Bast, Helen Kubis, Birte Holtfreter, Silvia Ribback, Heiner Martin, Helen C Schreiner, Malte J Dominik, Katrin Breitbach, Frank Dombrowski, Thomas Kocher and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Neutrophil Killing ofJournal of innate immunity · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. DNA Laddering to Evaluate Cytogenetic Damage in Patients with Periodontitis.Journal of International Society of Preventive & Community Dentistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Antje BastFriedrich Loeffler Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Helen KubisFriedrich Loeffler Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Birte HoltfreterUnit of Periodontology, Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany.
Silvia RibbackInstitute of Pathology, University Medicine Greifswald, Greifswald, Germany.
Heiner MartinInstitute for Biomedical Engineering, University of Rostock, Rostock, Germany.
Helen C SchreinerDepartment of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry, Newark, New Jersey, USA.
Malte J DominikFriedrich Loeffler Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Katrin BreitbachFriedrich Loeffler Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Frank DombrowskiInstitute of Pathology, University Medicine Greifswald, Greifswald, Germany.
Thomas KocherUnit of Periodontology, Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany.
Ivo SteinmetzFriedrich Loeffler Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany ivo.steinmetz@medunigraz.at.
Universitätsmedizin Greifswald · DEFriedrich-Loeffler-Institut · DEMedical University of Graz · ATRutgers, The State University of New Jersey · USUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aggregatibacter actinomycetemcomitans is a Gram-negative commensal bacterium of the oral cavity which has been associated with the pathogenesis of periodontitis with severe alveolar bone destruction. The role of host factors such as reactive oxygen and nitrogen intermediates in periodontal A. actinomycetemcomitans infection and progression to periodontitis is still ill-defined. Therefore, this study aimed to analyze the role of NADPH oxidase and inducible nitric oxide synthase (iNOS) in a murine model of A. actinomycetemcomitans-induced periodontitis. NADPH oxidase-deficient (gp91

Indexed as

Aggregatibacter actinomycetemcomitansDisease ResistanceAlveolar Bone LossAnimalsBacterial LoadBone DensityDisease Models, AnimalFemaleHost-Pathogen InteractionsMembrane GlycoproteinsMiceMice, KnockoutNADPH Oxidase 2NADPH OxidasesNitric Oxide Synthase Type IIOsteoclastsCybb protein, mouseMembrane GlycoproteinsNADPH Oxidase 2NADPH OxidasesNitric Oxide Synthase Type IIAggregatibacter actinomycetemcomitansalveolar bone lossbone mineral densitymicro-computed tomographyNADPH oxidaseperiodontal disease

Identifiers

PMID27849181
PMCPMC5278171
OpenAlexW2551209298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.