ArticleScientific reports2016
Analysis of Microarray Data on Gene Expression and Methylation to Identify Long Non-coding RNAs in Non-small Cell Lung Cancer.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 66 citations in OpenAlex.
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- Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs.Biomolecules · 2022Review
- Dysregulations of long non-coding RNAs - The emerging "lnc" in environmental carcinogenesis.Seminars in cancer biology · 2021Review
- LncRNA LOC146880 promotes esophageal squamous cell carcinoma progression via miR-328-5p/FSCN1/MAPK axis.Aging · 2021Article
- New Perspectives in Different Gene Expression Profiles for Early and Locally Advanced Non-Small Cell Lung Cancer Stem Cells.Frontiers in oncology · 2021Article
- Multiomics-based analyses of KPNA2 highlight its multiple potentials in hepatocellular carcinoma.PeerJ · 2021Article
- A SNP-mediated lncRNA (LOC146880) and microRNA (miR-539-5p) interaction and its potential impact on the NSCLC risk.Journal of experimental & clinical cancer research : CR · 2020Article
- Long non-coding RNA dysregulation is a frequent event in non-small cell lung carcinoma pathogenesis.British journal of cancer · 2020Article
- RCC2 Expression Stimulates ER-Positive Breast Tumorigenesis.Journal of oncology · 2020Article
- Regulator of Chromosome Condensation 2 Modulates Cell Cycle Progression, Tumorigenesis, and Therapeutic Resistance.Frontiers in molecular biosciences · 2020Review
- Epigenetics of lung cancer: a translational perspective.Cellular oncology (Dordrecht, Netherlands) · 2019Review
- Methylation and transcriptome analysis reveal lung adenocarcinoma-specific diagnostic biomarkers.Journal of translational medicine · 2019Article
- SNPs in LncRNA genes are associated with non-small cell lung cancer in a Chinese population.Journal of clinical laboratory analysis · 2019Article
- Knockdown of long non-coding RNACancer biology & medicine · 2018Article
- Molecular Signature for Lymphatic Invasion Associated with Survival of Epithelial Ovarian Cancer.Cancer research and treatment · 2018Article
- Long non-coding RNAs function as novel predictors and targets of non-small cell lung cancer: a systematic review and meta-analysis.Oncotarget · 2018Article
- Long non-coding RNAs involved in autophagy regulation.Cell death & disease · 2017Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
To identify what long non-coding RNAs (lncRNAs) are involved in non-small cell lung cancer (NSCLC), we analyzed microarray data on gene expression and methylation. Gene expression chip and HumanMethylation450BeadChip were used to interrogate genome-wide expression and methylation in tumor samples. Differential expression and methylation were analyzed through comparing tumors with adjacent non-tumor tissues. LncRNAs expressed differentially and correlated with coding genes and DNA methylation were validated in additional tumor samples using RT-qPCR and pyrosequencing. In vitro experiments were performed to evaluate lncRNA's effects on tumor cells. We identified 8,500 lncRNAs expressed differentially between tumor and non-tumor tissues, of which 1,504 were correlated with mRNA expression. Two of the lncRNAs, LOC146880 and ENST00000439577, were positively correlated with expression of two cancer-related genes, KPNA2 and RCC2, respectively. High expression of LOC146880 and ENST00000439577 were also associated with poor survival. Analysis of lncRNA expression in relation to DNA methylation showed that LOC146880 expression was down-regulated by DNA methylation in its promoter. Lowering the expression of LOC146880 or ENST00000439577 in tumor cells could inhibit cell proliferation, invasion and migration. Analysis of microarray data on gene expression and methylation allows us to identify two lncRNAs, LOC146880 and ENST00000439577, which may promote the progression of NSCLC.
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