ArticleScientific reports2016
The high-affinity metal Transporters NRAMP1 and IRT1 Team up to Take up Iron under Sufficient Metal Provision.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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61 citing papers in PubMed, 167 citations in OpenAlex.
- Effects of magnetic field-mediated plasma seed treatment and PPW spray: enhanced growth, nutritional composition and yield of tomatoes.RSC advances · 2026Article
- Aluminium Alleviates Manganese Toxicity by Regulating the CsNRAMP5 Transporter in Tea Plant (Camellia sinensis).Plant, cell & environment · 2026Article
- Transporter promiscuity and redox-driven metal partitioning in plant responses to chemically analogous metals.Plant cell reports · 2026Review
- Mechanisms underlying the accumulation and detoxification of manganese in Celosia argentea Linn. leaves.BMC plant biology · 2026Article
- Uncovering adaptation with a new Arabidopsis thaliana multiparent intercross population.Genetics · 2026Article
- Functional characterization of SmNRAMP1 allelic variants conferring reduced cadmium uptake in Salvia miltiorrhiza.BMC plant biology · 2026Article
- Identification of miRNAs Responsive to a Defined Period of Iron Deficiency and Resupply inPlants (Basel, Switzerland) · 2026Article
- Transcriptomic and physiological analyses revealed nicotianamine enhances wheat tolerance to excess manganese.iScience · 2025Article
- Growth-Promoting Effects and Mechanisms of Synthetic Plant Growth-Promoting Rhizobacteria on Maize Seedlings.Microorganisms · 2025Article
- The Rare Earth Element Lanthanum (La) Accumulates inPlants (Basel, Switzerland) · 2025Article
- Manganese handling in plants: Advances in the mechanistic and functional understanding of transport pathways.Quantitative plant biology · 2025Review
- Untangling iron threads: A deep dive into plant intracellular pools.Quantitative plant biology · 2025Review
- Soil and Mineral Nutrients in Plant Health: A Prospective Study of Iron and Phosphorus in the Growth and Development of Plants.Current issues in molecular biology · 2024Review
- Overexpression ofInternational journal of molecular sciences · 2023Article
- TaNRAMP3 is essential for manganese transport in Triticum aestivum.Stress biology · 2023Article
- Article
- Cell type-specific mapping of ion distribution in Arabidopsis thaliana roots.Nature communications · 2023Article
- Systematic Analysis of NRAMP Family Genes inInternational journal of molecular sciences · 2023Article
- Promotive Role of 5-Aminolevulinic Acid or Salicylic Acid Combined with Citric Acid on Sunflower Growth by Regulating Manganese Absorption.Antioxidants (Basel, Switzerland) · 2023Article
- Genome-Wide Identification and Expression Analysis Reveals Roles of theInternational journal of molecular sciences · 2023Article
1 more citing papers are in PubMed but not listed here.
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Iron (Fe) and manganese (Mn) are essential metals which, when scarce in the growth medium, are respectively taken up by the root high affinity transporters IRT1 and NRAMP1 in Arabidopsis thaliana. The molecular bases for low affinity transport however remained unknown. Since IRT1 and NRAMP1 have a broad range of substrates among metals, we tested the hypothesis that they might be functionally redundant by generating nramp1 irt1 double mutants. These plants showed extreme Fe-deficiency symptoms despite optimal provision of the metal. Their phenotype, which includes low Fe and Mn contents and a defect of Fe entry into root cells as revealed by Fe staining, is rescued by high Fe supply. Using a promoter swap-based strategy, we showed that root endodermis retains the ability to carry out high affinity Fe transport and furthermore might be important to high-affinity Mn uptake. We concluded that NRAMP1 plays a pivotal role in Fe transport by cooperating with IRT1 to take up Fe in roots under replete conditions, thus providing the first evidence for a low affinity Fe uptake system in plants.
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