ArticleScientific reports2016
The caste- and sex-specific DNA methylome of the termite Zootermopsis nevadensis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Meta-Analysis of Public RNA Sequencing Data Revealed Potential Key Genes Associated with Reproductive Division of Labor in Social Hymenoptera and Termites.International journal of molecular sciences · 2023Pooled it
- Genome Evolution in Social Insects.Genome biology and evolution · 2026Review
- Transcription Factor Evolution Associated with Social Transitions in Blattodea.Journal of molecular evolution · 2026Article
- Transcriptomic and DNA Methylation Profiles of Alternative Aphid Morphs and Genotypes.Ecology and evolution · 2026Article
- Arms races between selfish genetic elements and their host defence in termites.Nature communications · 2026Article
- Evolutionary Transitions in Social Behavior are Associated With Convergent and Partially Reversible Expansions of Transcription Factor Binding Sites.Genome biology and evolution · 2026Article
- miR-701 modulates the humoral immune response of Coptotermes formosanus against Metarhizium anisopliae.Insect science · 2025Article
- Transgenerational epigenetic effect of kings' aging on offspring's caste fate mediated by sperm DNA methylation in termites.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Oysters in transition: hermaphrodite oysters display unique DNA methylation patterns in gill tissue.BMC genomics · 2025Article
- Sexual epigenetics: genome-wide analysis revealed differential DNA methylation in the vector tick Haemaphysalis longicornis.Parasites & vectors · 2025Article
- Differential DNA methylation in response to host environment changes in Drosophila gouveai.Genetica · 2025Article
- The Molecular Substrates of Insect Eusociality.Annual review of genetics · 2024Review
- A plant virus differentially alters DNA methylation in two cryptic species of a hemipteran vector.Npj viruses · 2024Article
- Pervasive relaxed selection in termite genomes.Proceedings. Biological sciences · 2024Article
- Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants.Cell · 2023Article
- Genome-wide DNA methylation patterns in bumble bee (Bombus vosnesenskii) populations from spatial-environmental range extremes.Scientific reports · 2023Article
- Integrated Analysis of DNA Methylome and Transcriptome Reveals Epigenetic Regulation of Cold Tolerance inInternational journal of molecular sciences · 2023Article
- Associations between DNA methylation and gene regulation depend on chromatin accessibility during transgenerational plasticity.BMC biology · 2023Article
- Allele-specific cis-regulatory methylation of the gene for vasoactive intestinal peptide in white-throated sparrows.Genes, brain, and behavior · 2022Article
- Complex regulatory role of DNA methylation in caste- and age-specific expression of a termite.Open biology · 2022Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic inheritance plays an important role in mediating alternative phenotype in highly social species. In order to gain a greater understanding of epigenetic effects in societies, we investigated DNA methylation in the termite Zootermopsis nevadensis. Termites are the most ancient social insects, and developmentally distinct from highly-studied, hymenopteran social insects. We used replicated bisulfite-sequencing to investigate patterns of DNA methylation in both sexes and among castes of Z. nevadensis. We discovered that Z. nevadensis displayed some of the highest levels of DNA methylation found in insects. We also found strong differences in methylation between castes. Methylated genes tended to be uniformly and highly expressed demonstrating the antiquity of associations between intragenic methylation and gene expression. Differentially methylated genes were more likely to be alternatively spliced than not differentially methylated genes, and possessed considerable enrichment for development-associated functions. We further observed strong overrepresentation of multiple transcription factor binding sites and miRNA profiles associated with differential methylation, providing new insights into the possible function of DNA methylation. Overall, our results show that DNA methylation is widespread and associated with caste differences in termites. More generally, this study provides insights into the function of DNA methylation and the success of insect societies.
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