ArticleNature communications2016
Mechanical gating of a mechanochemical reaction cascade.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Article
- Stretching decelerates ring-opening metathesis at cis-olefins in stressed molecular bows.Nature communications · 2026Article
- Revealing Hidden Length by Force: Decoupling Modulus and Toughness in Network Gels.ACS central science · 2025Article
- Computational Exploration of Polymer Mechanochemistry: Quantitation of Activation Force and Systematic Discovery of Reaction Sites by the Extended Artificial Force-Induced Reaction Method.Journal of the American Chemical Society · 2025Article
- Logic-Gated Release of a Dual Payload from a β-Lactam Mechanophore with a Rotaxane Actuator.Angewandte Chemie (International ed. in English) · 2025Article
- Force-Accelerated Ring Opening of Episulfide by Pulsed Ultrasonication.Macromolecules · 2025Article
- Mechanochemistry: Fundamental Principles and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Advancing the Mechanosensitivity of Atropisomeric Diarylethene Mechanophores through a Lever-Arm Effect.Journal of the American Chemical Society · 2025Article
- Mechanical scission of a knotted polymer.Nature chemistry · 2024Article
- Mechanochemical Approaches to Fundamental Studies in Soft-Matter Physics.Angewandte Chemie (International ed. in English) · 2024Review
- Sacrificial Mechanical Bond is as Effective as a Sacrificial Covalent Bond in Increasing Cross-Linked Polymer Toughness.Journal of the American Chemical Society · 2023Article
- Coumarin Dimer Is an Effective Photomechanochemical AND Gate for Small-Molecule Release.Journal of the American Chemical Society · 2023Article
- Editing of polymer backbones.Nature reviews. Chemistry · 2023Review
- Force-Triggered Atropisomerization of a Parallel Diarylethene to Its Antiparallel Diastereomers.Journal of the American Chemical Society · 2023Article
- Swelling-Activated, Soft Mechanochemistry in Polymer Materials.Langmuir : the ACS journal of surfaces and colloids · 2023Review
- Bond breaking of furan-maleimide adductsChemical science · 2023Article
- Mechanochemically accessing a challenging-to-synthesize depolymerizable polymer.Nature communications · 2023Article
- Force Dependent Barriers from Analytic Potentials within Elastic Environments.Chemphyschem : a European journal of chemical physics and physical chemistry · 2022Article
- Force-reversible chemical reaction at ambient temperature for designing toughened dynamic covalent polymer networks.Nature communications · 2022Article
- Release of Molecular Cargo from Polymer Systems by Mechanochemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Covalent polymer mechanochemistry offers promising opportunities for the control and engineering of reactivity. To date, covalent mechanochemistry has largely been limited to individual reactions, but it also presents potential for intricate reaction systems and feedback loops. Here we report a molecular architecture, in which a cyclobutane mechanophore functions as a gate to regulate the activation of a second mechanophore, dichlorocyclopropane, resulting in a mechanochemical cascade reaction. Single-molecule force spectroscopy, pulsed ultrasonication experiments and DFT-level calculations support gating and indicate that extra force of >0.5 nN needs to be applied to a polymer of gated gDCC than of free gDCC for the mechanochemical isomerization gDCC to proceed at equal rate. The gating concept provides a mechanism by which to regulate stress-responsive behaviours, such as load-strengthening and mechanochromism, in future materials designs.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.