ArticleHeredity2017
Uncovering the genetic signature of quantitative trait evolution with replicated time series data.
Article in Heredity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Haplotype structure: an overlooked key factor shaping the genomic selection response.Genetics · 2026Article
- PolyAdapt: Characterizing Polygenic Adaptive Architectures in the Presence of Strong Linkage Disequilibrium.Genome biology and evolution · 2026Article
- Evolutionary Dynamics of Gene Expression During Thermal Adaptation in Drosophila subobscura.Genome biology and evolution · 2026Article
- Genomic evidence for fisheries-induced evolution in Eastern Baltic cod.Science advances · 2025Article
- Reduced Parallel Gene Expression Evolution With Increasing Genetic Divergence-A Hallmark of Polygenic Adaptation.Molecular ecology · 2025Article
- Microevolutionary change in wild stickleback: Using integrative time-series data to infer responses to selection.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Evolution of Phenotypic Variance Provides Insights into the Genetic Basis of Adaptation.Genome biology and evolution · 2024Article
- Unraveling the Molecular Basis of Stabilizing Selection by Experimental Evolution.Genome biology and evolution · 2023Article
- Review
- Artificial selection reveals complex genetic architecture of shoot branching and its response to nitrate supply in Arabidopsis.PLoS genetics · 2023Article
- Genome-wide signatures of synergistic epistasis during parallel adaptation in a Baltic Sea copepod.Nature communications · 2022Article
- Genome-wide evolutionary response of European oaks during the Anthropocene.Evolution letters · 2022Article
- Long-term gut microbiome dynamics inProceedings. Biological sciences · 2021Article
- Highly Parallel Genomic Selection Response in Replicated Drosophila melanogaster Populations with Reduced Genetic Variation.Genome biology and evolution · 2021Article
- Finding Hybrid Incompatibilities Using Genome Sequences from Hybrid Populations.Molecular biology and evolution · 2021Article
- The genetic architecture of temperature adaptation is shaped by population ancestry and not by selection regime.Genome biology · 2021Article
- Experimental evolution of adaptive divergence under varying degrees of gene flow.Nature ecology & evolution · 2021Article
- Detecting selected haplotype blocks in evolve and resequence experiments.Molecular ecology resources · 2021Article
- Polygenic adaptation: a unifying framework to understand positive selection.Nature reviews. Genetics · 2020Review
- The Effects of Quantitative Trait Architecture on Detection Power in Short-Term Artificial Selection Experiments.G3 (Bethesda, Md.) · 2020Article
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3 authors.
Funding
Abstract
The genetic architecture of adaptation in natural populations has not yet been resolved: it is not clear to what extent the spread of beneficial mutations (selective sweeps) or the response of many quantitative trait loci drive adaptation to environmental changes. Although much attention has been given to the genomic footprint of selective sweeps, the importance of selection on quantitative traits is still not well studied, as the associated genomic signature is extremely difficult to detect. We propose 'Evolve and Resequence' as a promising tool, to study polygenic adaptation of quantitative traits in evolving populations. Simulating replicated time series data we show that adaptation to a new intermediate trait optimum has three characteristic phases that are reflected on the genomic level: (1) directional frequency changes towards the new trait optimum, (2) plateauing of allele frequencies when the new trait optimum has been reached and (3) subsequent divergence between replicated trajectories ultimately leading to the loss or fixation of alleles while the trait value does not change. We explore these 3 phase characteristics for relevant population genetic parameters to provide expectations for various experimental evolution designs. Remarkably, over a broad range of parameters the trajectories of selected alleles display a pattern across replicates, which differs both from neutrality and directional selection. We conclude that replicated time series data from experimental evolution studies provide a promising framework to study polygenic adaptation from whole-genome population genetics data.
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