Evidence map›Paper›PMID 27848894›Full record

ReviewCurrent topics in medicinal chemistry2017

LncRNA as a Therapeutic Target for Angiogenesis.

Mohan M Kumar, Ravi Goyal

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current topics in medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed, 3 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 3 syntheses or guidelines pooled it, 265 citations in OpenAlex.

  1. Pooled it
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  15. The Role of Long Intergenic Noncoding RNA in Fetal Development.International journal of molecular sciences · 2024
    Review
  16. Long Noncoding RNA MALAT1: Salt-Sensitive Hypertension.International journal of molecular sciences · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. Article

99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mohan M KumarLawrence D. Longo MD Center for Perinatal Biology, Loma Linda University, Loma Linda, CA, United States.
Ravi GoyalLawrence D. Longo MD Center for Perinatal Biology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, United States.
Loma Linda University · US

Funding

Role of LincRNA in Developmental Regulation of AngiogenesisR21HD081283 · NICHD · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J. · 2014 to 2015
$430k
6 · The paper itself

Abstract

backgroundOut of 3 billion base pairs in human genome only ~2% code for proteins; and out of 180,000 transcripts in human cells, about 20,000 code for protein, remaining 160,000 are non-coding transcripts. Most of these transcripts are more than 200 base pairs and constitute a group of long non-coding RNA (lncRNA). Many of the lncRNA have its own promoter, and are well conserved in mammals. Accumulating evidence indicates that lncRNAs act as molecular switches in cellular differentiation, movement, apoptosis, and in the reprogramming of cell states by altering gene expression patterns. However, the role of this important group of molecules in angiogenesis is not well understood. Angiogenesis is a complex process and depends on precise regulation of gene expression.

conclusionDysregulation of transcription during this process may lead to several diseases including various cancers. As angiogenesis is an important process in cancer pathogenesis and treatment, lncRNA may be playing an important role in angiogenesis. In support of this, lncRNA microvascular invasion in hepatocellular carcinoma (MVIH) has been shown to activate angiogenesis. Furthermore, lncRNA-Meg3-knockout mouse showed increased expression of vascular endothelial growth factor pathway genes and increased cortical microvessel density. Overall, there is strong evidence that lncRNA is an important class of regulatory molecule, and a number of studies have demonstrated that these can be targeted to change cellular physiology and functions. In this review, we have attempted to summarize these studies and elucidate the potential of this novel regulatory molecule as a therapeutic target.

Indexed as

AnimalsCarcinoma, HepatocellularHumansLiver NeoplasmsNeovascularization, PathologicRNA, Long NoncodingRNA, Long NoncodingEpigenetic regulationgene expressionintervening noncoding RNALinc-MD1LncRNA

Identifiers

PMID27848894
PMCPMC5421140
OpenAlexW2552336026

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.