Evidence map›Paper›PMID 27848227›Full record

ArticleJournal of nephrology2018

The clinical implications of the unique glomerular complement deposition pattern in transplant glomerulopathy.

Priya S Verghese, Robin C Reed, Bu Lihong, Arthur J Matas, Youngki Kim

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Transplant glomerulopathy.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Priya S VergheseDivision of Pediatric Nephrology, University of Minnesota, Minneapolis, USA. pverghes@umn.edu.ORCID http://orcid.org/0000-0002-8836-0881
Robin C ReedDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, USA.
Bu LihongDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, USA.
Arthur J MatasDepartment of Surgery, University of Minnesota, Minneapolis, USA.
Youngki KimDivision of Pediatric Nephrology, University of Minnesota, Minneapolis, USA.
University of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The etiology and treatment of transplant glomerulopathy (TG) is not clear. TG is associated with donor-specific antibodies but the lack of C4d deposition in the peritubular capillaries (ptc-C4d) in some cases has caused the role of complement in the pathogenesis of TG to be debated. There is however, little information on C4d deposition in the glomerulus itself. We retrieved random frozen sections from 25 cases with well-established TG by light microscopy (LM) and 25 cases without TG as controls and reviewed the LM and immunofluorescence (nine biopsies were excluded due to inadequate samples). Glomerular complement deposition was assessed in all included biopsies. Glomerular C3d and C4d deposition occurred in a distinct pattern in all TG biopsies: segmental or global double linear staining of the glomerular capillary wall in 23 (100%). This pattern was not present in any NON-TG biopsies. The distinct glomerular complement deposition patterns in all TG cases are suggestive that TG is a proximal complement-mediated process and therapies should focus on proximal complement inhibition.

Indexed as

BiomarkersCase-Control StudiesComplement ActivationComplement C3dComplement C4bFluorescent Antibody TechniqueFrozen SectionsHumansKidney DiseasesKidney GlomerulusKidney TransplantationPeptide FragmentsBiomarkersComplement C3dComplement C4bcomplement C4dPeptide FragmentsAntibody mediated rejectionChronic graft lossChronic rejectionComplementComplement inhibitionTG

Identifiers

PMID27848227
OpenAlexW2551708386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.