ArticleJournal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology2017
Incidence and predictive risk factors of postoperative sepsis in orthopedic trauma patients.
Article in Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Risk factors for sepsis: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Complete Blood Count and Monocyte Distribution Width-Based Machine Learning Algorithms for Sepsis Detection: Multicentric Development and External Validation Study.Journal of medical Internet research · 2025Article
- Global incidence and risk factors for injury-related bloodstream infections: a scoping review.Epidemiologic reviews · 2025Article
- Nutritional status is associated with inferior clinical outcomes: A National Surgical Quality Improvement Project analysis of surgically treated spinal vascular lesions.Surgical neurology international · 2025Article
- Identifying predictors of nosocomial pneumonia in trauma patients admitted to a level-1 trauma center.Archives of orthopaedic and trauma surgery · 2024Article
- Antimicrobials in Orthopedic Infections: Overview of Clinical Perspective and Microbial Resistance.Medicina (Kaunas, Lithuania) · 2024Review
- Liver Disease Increases the Risk of Postoperative Complications in Patients Undergoing Aseptic Revision Total Hip and Knee Arthroplasty.Arthroplasty today · 2024Article
- NSQIP data collection up to 30 postoperative days is sufficient to capture some complications in orthopedic surgeries.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Trauma diagnostic-related target proteins and their detection techniques.Expert reviews in molecular medicine · 2024Review
- Predictors of sepsis in trauma patients: a National Trauma Data Bank analysis.Frontiers in medicine · 2024Article
- Diabetes mellitus as a risk factor for postoperative complications following arthroscopic rotator cuff repair.JSES international · 2023Article
- Orthopaedic Surgery Complications at a Tertiary Care Hospital in a Low- and Middle-Income Country: A National Surgical Quality Improvement Project Analysis.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2023Article
- Cardiovascular parameters on computed tomography are independently associated with in-hospital complications and outcomes in level-1 trauma patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Incidence and risk factors for surgical site infection following volar locking plating (VLP) of unstable distal radius fracture (DRF).Journal of orthopaedic surgery and research · 2022Article
- The Toxicity and Antibacterial Effects of Povidone-Iodine Irrigation in Fracture Surgery.Orthopaedic surgery · 2022Article
- Cost of postoperative sepsis in Vietnam.Scientific reports · 2022Article
- Management of superficial and deep surgical site infection: an international multidisciplinary consensus.Updates in surgery · 2021Article
- Sepsis, Cytokine Storms, and Immunopathology: The Divide between Neonates and Adults.ImmunoHorizons · 2021Article
- Early Outcomes After Surgical Management of Geriatric Patella Fractures.Geriatric orthopaedic surgery & rehabilitation · 2021Article
- Sepsis and septic shock after craniotomy: Predicting a significant patient safety and quality outcome measure.PloS one · 2020Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative sepsis is associated with high mortality and the national costs of septicemia exceed those of any other diagnosis. While numerous studies in the basic orthopedic science literature suggest that traumatic injuries facilitate the development of sepsis, it is currently unclear whether orthopedic trauma patients are at increased risk. The purpose of this study was thus to assess the incidence of sepsis and determine the risk factors that significantly predicted septicemia following orthopedic trauma surgery. MATERIALS AND
methods56,336 orthopedic trauma patients treated between 2006 and 2013 were identified in the ACS-NSQIP database. Documentation of postoperative sepsis/septic shock, demographics, surgical variables, and preoperative comorbidities was collected. Chi-squared analyses were used to assess differences in the rates of sepsis between trauma and nontrauma groups. Binary multivariable regressions identified risk factors that significantly predicted the development of postoperative septicemia in orthopedic trauma patients.
resultsThere was a significant difference in the overall rates of both sepsis and septic shock between orthopedic trauma (1.6%) and nontrauma (0.5%) patients (p < 0.001). For orthopedic trauma patients, ventilator use (OR = 15.1, p = 0.002), history of pain at rest (OR = 2.8, p = 0.036), and prior sepsis (OR = 2.6, p < 0.001) were significantly associated with septicemia. Statistically predictive, modifiable comorbidities included hypertension (OR = 2.1, p = 0.003) and the use of corticosteroids (OR = 2.1, p = 0.016).
conclusionsThere is a significantly greater incidence of postoperative sepsis in the trauma cohort. Clinicians should be aware of these predictive characteristics, may seek to counsel at-risk patients, and should consider addressing modifiable risk factors such as hypertension and corticosteroid use preoperatively. Level of evidence Level III.
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