Evidence map›Paper›PMID 27847648›Full record

ArticleNeural plasticity2016

Increases in Retrograde Injury Signaling Complex-Related Transcripts in Central Axons following Injury.

Gunja K Pathak, Hannah Ornstein, Helim Aranda-Espinoza, Amy J Karlsson, Sameer B Shah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gunja K PathakFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Hannah OrnsteinFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Helim Aranda-EspinozaFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Amy J KarlssonDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, USA.
Sameer B ShahFischell Department of Bioengineering, University of Maryland, College Park, MD, USA; Departments of Orthopaedic Surgery and Bioengineering, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-6613-3904
University of Maryland, College Park · USUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Axons in the peripheral nervous system respond to injury by activating retrograde injury signaling (RIS) pathways, which promote local axonal protein synthesis (LPS) and neuronal regeneration. RIS is also initiated following injury of neurons in the central nervous system (CNS). However, regulation of the localization of axonal mRNA required for LPS is not well understood. We used a hippocampal explant system to probe the regulation of axonal levels of RIS-associated transcripts following axonal injury. Axonal levels of importin

Indexed as

Signal TransductionActinsAnimalsAxonsAxotomyCells, CulturedGanglia, SpinalHippocampusMiceNerve RegenerationPeripheral Nerve InjuriesActins

Identifiers

PMID27847648
PMCPMC5099454
OpenAlexW2537113430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.