Evidence map›Paper›PMID 27847629›Full record

ReviewInternational journal of retina and vitreous2016

Human retinal microvascular imaging using adaptive optics scanning light ophthalmoscopy.

Toco Y P Chui, Shelley Mo, Brian Krawitz, Nikhil R Menon, Nadim Choudhury, Alexander Gan, Moataz Razeen, Nishit Shah, Alexander Pinhas, Richard B Rosen

Open access · goldAbstract readReview
In one paragraph

Review in International journal of retina and vitreous, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Characterization ofInternational journal of endocrinology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Toco Y P ChuiDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY USA.
Shelley MoDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY USA.
Brian KrawitzDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY USA.
Nikhil R MenonDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY USA.
Nadim ChoudhuryDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY USA.
Alexander GanDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY USA.
Moataz RazeenDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY USA.
Nishit ShahDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY USA.
Alexander PinhasDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY USA.
Richard B RosenDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY USA.
New York Eye and Ear Infirmary · USAlexandria University · EGIcahn School of Medicine at Mount Sinai · US

Funding

MORPHOLOGY MODULEP30EY001931 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI LINK, BRIAN A · 1985 to 2016
$9.8M
Platform Technologies for Microscopic Retinal Imaging: Development & TranslationU01EY025477 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2015 to 2019
$4.4M
Characterization of vascular responses to intravitreal anti-VEGF injections in diabetic retinopathyR01EY027301 · NEI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Yuen Ping Toco Chui · 2017 to 2026
$4.0M
NEI NIH HHS P30 EY001931NEI NIH HHS R01 EY027301NEI NIH HHS U01 EY025477
6 · The paper itself

Abstract

backgroundRetinal microvascular imaging is an especially promising application of high resolution imaging since there are increasing options for therapeutic intervention and need for better structural and functional biomarkers to characterize ocular and systemic vascular diseases. MAIN BODY: Adaptive optics scanning light ophthalmoscopy (AOSLO) is an emerging technology for improving in vivo imaging of the human retinal microvasculature, allowing unprecedented visualization of retinal microvascular structure, measurements of blood flow velocity, and microvascular network mapping. This high resolution imaging technique shows significant potential for studying physiological and pathological conditions of the retinal microvasculature noninvasively.

conclusionThis review will briefly summarize the abilities of in vivo human retinal microvasculature imaging in healthy controls, as well as patients with diabetic retinopathy, retinal vein occlusion, and sickle cell retinopathy using AOSLO and discuss its potential contribution to scientific research and clinical applications.

Indexed as

Adaptive opticsBlood vesselsCapillariesDiabetic retinopathyFluorescein angiographyRetinaRetinal vein occlusionSickle cell retinopathy

Identifiers

PMID27847629
PMCPMC5088465
OpenAlexW2312874859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.