Evidence map›Paper›PMID 27847590›Full record

ArticleBJPsych open2016

Interhemispheric functional disconnection because of abnormal corpus callosum integrity in bipolar disorder type II.

Fumihiko Yasuno, Takashi Kudo, Kiwamu Matsuoka, Akihide Yamamoto, Masato Takahashi, Jyoji Nakagawara, Kazuyuki Nagatsuka, Hidehiro Iida, Toshifumi Kishimoto

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In one paragraph

Article in BJPsych open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Article
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  6. Article
  7. Resilience and White Matter Integrity in Geriatric Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018
    Article
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fumihiko Yasuno, MD, PhD, Department of Psychiatry, Nara Medical University, Kashihara, Japan; Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
Takashi Kudo, MD, PhD, Department of Psychiatry, Osaka University Health Care Center, Toyonaka, Japan.
Kiwamu Matsuoka, MD, Department of Psychiatry, Nara Medical University, Kashihara, Japan.
Akihide Yamamoto, MS, Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Suita, Japan.
Masato Takahashi, MD, Department of Psychiatry, Nara Medical University, Kashihara, Japan.
Jyoji Nakagawara, MD, PhD, Integrative Stroke Imaging Center, National Cerebral and Cardiovascular Center, Suita, Japan.
Kazuyuki Nagatsuka, MD, PhD, National Cerebral and Cardiovascular Center, Suita, Japan.
Hidehiro Iida, PhD, National Cerebral and Cardiovascular Center, Suita, Japan.
Toshifumi Kishimoto, MD, PhD, Department of Psychiatry, Nara Medical University, Kashihara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA significantly lower fractional anisotropy (FA) value has been shown in anterior parts of the corpus callosum in patients with bipolar disorder.

aimsWe investigated the association between abnormal corpus callosum integrity and interhemispheric functional connectivity (IFC) in patients with bipolar disorder.

methodsWe examined the association between FA values in the corpus callosum (CC-FA) and the IFC between homotopic regions in the anterior cortical structures of bipolar disorder (

resultsWe found a positive correlation between the CC-FA and IFC values between homotopic regions of the ventral prefrontal cortex and insula cortex, and significantly lower IFC between these regions in bipolar disorder patients.

conclusionsThe abnormal corpus callosum integrity in bipolar disorder patients is relevant to the IFC between homotopic regions, possibly disturbing the exchange of emotional information between the cerebral hemispheres resulting in emotional dysregulation. DECLARATION OF INTEREST: None. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.

Identifiers

PMID27847590
PMCPMC5100603

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.