ArticleJournal of Korean Neurosurgical Society2016
The Effect of Perioperative Radiation Therapy on Spinal Bone Fusion Following Spine Tumor Surgery.
Article in Journal of Korean Neurosurgical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The effect of radiotherapy, chemotherapy, and immunotherapy on fusion rate in spinal surgery using osteobiologics for patients with metastatic spinal disease: a systematic review.Neurosurgical review · 2024Pooled it
- AO Spine Clinical Practice Recommendations: An Overview of the Current State of Fusion Surgery for Patients With Spinal Metastasis: Is Fusion Necessary?Global spine journal · 2026Article
- Review
- Imaging evidence of osseous fusion of patients undergoing segmental mandibular fibular free flap reconstruction - a retrospective analysis.Journal of clinical imaging science · 2026Article
- Intramedullary spinal cord metastasis treated with prophylactic laminoplasty prior to radiation to the spinal cord: a case report.Journal of spine surgery (Hong Kong) · 2023Article
- Focused versus conventional radiotherapy in spinal oncology: is there any difference in fusion rates and pseudoarthrosis?Journal of neuro-oncology · 2022Article
- An Overview of Decision Making in the Management of Metastatic Spinal Tumors.Indian journal of orthopaedics · 2021Review
- Vascularized Rib Bone Grafting: Indications, Techniques, and Clinical Outcomes.Seminars in plastic surgery · 2021Review
- Factors Related to Instrumentation Failure in Titanium Mesh Reconstruction for Thoracic and Lumbar Tumors: Retrospective Analysis of 178 Patients.Cancer management and research · 2021Article
- Basic concepts in metal work failure after metastatic spine tumour surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2018Review
- Instrumented Spinal Stabilization without Fusion for Spinal Metastatic Disease.World neurosurgery · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPerioperative irradiation is often combined with spine tumor surgery. Radiation is known to be detrimental to healing process of bone fusion. We tried to investigate bone fusion rate in spine tumor surgery cases with perioperative radiation therapy (RT) and to analyze significant factors affecting successful bone fusion.
methodsStudy cohort was 33 patients who underwent spinal tumor resection and bone graft surgery combined with perioperative RT. Their medical records and radiological data were analyzed retrospectively. The analyzed factors were surgical approach, location of bone graft (anterior vs. posterior), kind of graft (autologous graft vs. allograft), timing of RT (preoperative vs. postoperative), interval of RT from operation in cases of postoperative RT (within 1 month vs. after 1 month) radiation dose (above 38 Gy vs. below 38 Gy) and type of radiation therapy (conventional RT vs. stereotactic radiosurgery). The bone fusion was determined on computed tomography images.
resultBone fusion was identified in 19 cases (57%). The only significant factors to affect bony fusion was the kind of graft (75% in autograft vs. 41 in allograft,
conclusionSpinal fusion surgery which was combined with perioperative RT showed relatively low bone fusion rate (57%). For successful bone fusion, the selection of bone graft was the most important.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.