Evidence map›Paper›PMID 27847559›Full record

ArticleWorld journal of cardiology2016

Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure.

Tien Mh Ng, Myron L Toews

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

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  13. Heart failure and COVID-19.Heart failure reviews · 2021
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  18. What Is the Impact of Baseline Inflammatory and Hemostatic Indicators with the Risk of Mortality in Severe Inpatients with COVID-19: A Retrospective Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Tien Mh NgTien MH Ng, Myron L Toews, University of Nebraska Medical Center, Omaha, NE 68198, United States.
Myron L ToewsTien MH Ng, Myron L Toews, University of Nebraska Medical Center, Omaha, NE 68198, United States.
University of Nebraska Medical Center · USUniversity of Southern California · US

Funding

Research Pilot Project ProgramP30GM106397 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI JOHNSON, KEITH R · 2013 to 2017
$4.9M
NIGMS NIH HHS P30 GM106397
6 · The paper itself

Abstract

aimTo evaluate the effect of norepinephrine on inflammatory cytokine expression in

methodsFor human monocyte studies, cells were isolated from 12 chronic heart failure (HF) (66 ± 12 years, New York Heart Association functional class III-IV, left ventricular ejection fraction 22% ± 9%) and 14 healthy subjects (66 ± 12 years). Monocytes (1 × 10

resultsBasal TNFα concentrations were higher in HF vs healthy subjects (6.3 ± 3.3 pg/mL

conclusionNE regulation of monocyte inflammatory cytokine production may be reduced in moderate-severe HF, and may be mediated through β-adrenergic receptors.

Indexed as

CytokinesHeart failureInflammationMonocytes

Identifiers

PMID27847559
PMCPMC5088364
OpenAlexW2544926600

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.