ArticleFrontiers in behavioral neuroscience2016
Pupil Dynamics Reflect Behavioral Choice and Learning in a Go/NoGo Tactile Decision-Making Task in Mice.
Article in Frontiers in behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Pupil Reactions to Tactile Stimulation: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
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- Most Ventral Pallidal Cholinergic Neurons Are Bursting Basal Forebrain Cholinergic Neurons with Mesocorticolimbic Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Behavioral state-dependent norepinephrine dynamics in the primary somatosensory and prefrontal cortices during tactile detection tasks.bioRxiv : the preprint server for biology · 2026Article
- Context-dependent activation of V1 parvalbumin interneurons enhances visual discrimination.PLoS biology · 2025Article
- Pupil responses to social stimuli are associated with adaptive behaviors across the first 24 months of life.Journal of neurodevelopmental disorders · 2025Article
- Role of posterior medial thalamus in the modulation of striatal circuitry and choice behavior.eLife · 2025Article
- Imaging the large-scale and cellular response to focal traumatic brain injury in mouse neocortex.Experimental physiology · 2025Article
- Imaging the large-scale and cellular response to focal traumatic brain injury in mouse neocortex.bioRxiv : the preprint server for biology · 2024Article
- Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus.Nature neuroscience · 2024Article
- Separating cognitive and motor processes in the behaving mouse.bioRxiv : the preprint server for biology · 2024Article
- Adaptive decision-making depends on pupil-linked arousal in rats performing tactile discrimination tasks.Journal of neurophysiology · 2023Article
- Sensory suppression and increased neuromodulation during actions disrupt memory encoding of unpredictable self-initiated stimuli.Psychophysiology · 2023Article
- From pupil to the brain: New insights for studying cortical plasticity through pupillometry.Frontiers in neural circuits · 2023Review
- Pupil size changes reveal dogs' sensitivity to motion cues.iScience · 2022Article
- Neuronal correlates of the subjective experience of attention.The European journal of neuroscience · 2022Article
- Article
- Predicting Product Preferences on Retailers' Web Shops through Measurement of Gaze and Pupil Size Dynamics.Journal of cognition · 2022Article
- Pupillary dynamics of mice performing a Pavlovian delay conditioning task reflect reward-predictive signals.Frontiers in systems neuroscience · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The eye's pupil undergoes dynamic changes in diameter associated with cognitive effort, motor activity and emotional state, and can be used to index brain state across mammalian species. Recent studies in head-fixed mice have linked arousal-related pupil dynamics with global neural activity as well as the activity of specific neuronal populations. However, it has remained unclear how pupil dynamics in mice report trial-by-trial performance of behavioral tasks, and change on a longer time scale with learning. We measured pupil dynamics longitudinally as mice learned to perform a Go/NoGo tactile decision-making task. Mice learned to discriminate between two textures presented to the whiskers by licking in response to the Go texture (Hit trial) or withholding licking in response to the NoGo texture (Correct Reject trial, CR). Characteristic pupil dynamics were associated with behavioral choices: large-amplitude pupil dilation prior to and during licking accompanied Hit and False Alarm (FA) responses, while smaller amplitude dilation followed by constriction accompanied CR responses. With learning, the choice-dependent pupil dynamics became more pronounced, including larger amplitude dilations in both Hit and FA trials and earlier onset dilations in Hit and CR trials. A more pronounced constriction was also present in CR trials. Furthermore, pupil dynamics predicted behavioral choice increasingly with learning to greater than 80% accuracy. Our results indicate that pupil dynamics reflect behavioral choice and learning in head-fixed mice, and have implications for understanding decision- and learning-related neuronal activity in pupil-linked neural circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.