ArticleFrontiers in neuroscience2016
Enhanced Gamma Oscillatory Activity in Rats with Chronic Inflammatory Pain.
Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- High-Frequency Spinal Cord Stimulation Modifies Tibial Nerve-Stimulation-Evoked Cortical Theta-Gamma Coupling in Sheep Cortex.The European journal of neuroscience · 2026Article
- Targeting the Medial Prefrontal Cortex with Transcranial Focused Ultrasound Alleviates Adolescent Sleep-Deprivation-Induced Persistent Postsurgical Pain in Adulthood.Research (Washington, D.C.) · 2026Article
- Modulating Gamma Oscillations in the Anterior Cingulate Cortex with Intermittent Theta Burst Stimulation: Implications for Chronic Non-Specific Low Back Pain.Journal of pain research · 2025Review
- Altered neural oscillation patterns and functional connectivity in postherpetic neuralgia: evidence from resting-state EEG.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Brain structure and cortical activity changes of new daily persistent headache: multimodal evidence from MEG/sMRI.The journal of headache and pain · 2023Article
- Electrocorticography to Investigate Age-Related Brain Lateralization on Pediatric Motor Inhibition.Frontiers in neurology · 2022Article
- Neocortical circuits in pain and pain relief.Nature reviews. Neuroscience · 2021Review
- Intracortical Localization of a Promising Pain Biomarker.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Ketamine normalizes high-gamma power in the anterior cingulate cortex in a rat chronic pain model.Molecular brain · 2020Article
- Analgesic Effects of Compression at Trigger Points Are Associated With Reduction of Frontal Polar Cortical Activity as Well as Functional Connectivity Between the Frontal Polar Area and Insula in Patients With Chronic Low Back Pain: A Randomized Trial.Frontiers in systems neuroscience · 2019Article
- Membrane potential synchrony of neurons in anterior cingulate cortex plays a pivotal role in generation of neuropathic pain.Scientific reports · 2018Article
- Elevated Resting State Gamma Oscillatory Activities in Electroencephalogram of Patients With Post-herpetic Neuralgia.Frontiers in neuroscience · 2018Article
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Authors and funding
5 authors.
Funding
Abstract
It has been reported that oscillatory gamma activity participates in brief acute pain and tonic ongoing pain. It is of great interest to determine whether the gamma activity is involved in chronic pain since chronic pain is a more severe pathological condition characterized by pain persistency. To investigate the oscillatory gamma activity in chronic pain, in the present study, we recorded spontaneous electrocorticogram (ECoG) signals during chronic pain development in rats with chronic inflammatory pain induced by monoarthritis. Power spectrum analysis of ECoG data showed that gamma power increased significantly at the late stage of chronic inflammatory pain. The increased gamma activity occurred mainly at electrodes over primary somatosensory cortices. In rats with chronic pain, the gamma power was positively correlated with the hyperalgesia measured by laser energy that elicited hindpaw withdrawal response. Furthermore, an increased coupling between the amplitude of gamma power and the phase of theta oscillations was observed in chronic inflammatory pain condition. These results indicate an enhanced spontaneous gamma activity in chronic pain and suggest a potential biomarker for the severity of chronic pain.
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