Evidence map›Paper›PMID 27847358›Full record

ArticleJournal of virology2017

PrP Knockout Cells Expressing Transmembrane PrP Resist Prion Infection.

Karen E Marshall, Andrew Hughson, Sarah Vascellari, Suzette A Priola, Akikazu Sakudo, Takashi Onodera, Gerald S Baron

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. A Neuronal Cell Line Model for Studying Camel Prions.Pathogens (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. A New Take on Prion Protein Dynamics in Cellular Trafficking.International journal of molecular sciences · 2020
    Review
  10. Article
  11. Article
  12. Dual role of cellular prion protein in normal host and Alzheimer's disease.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Karen E MarshallRocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Andrew HughsonRocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Sarah VascellariRocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Suzette A PriolaRocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Akikazu SakudoResearch Center for Food Safety, School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan.
Takashi OnoderaResearch Center for Food Safety, School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan.
Gerald S BaronRocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA geraldsbaron@gmail.com.
National Institutes of Health · USThe University of Tokyo · JPNational Institute of Allergy and Infectious Diseases · US

Funding

Molecular Genetics Of Scrapie PathogenesisZIAAI000752 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI PRIOLA, SUZETTE ALISE · 2009 to 2025
$15.5M
TSE/Prion Cell BiologyZ01AI000982 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI BARON, GERALD · 2006 to 2008
$1.9M
Intramural NIH HHS Z01 AI000982
6 · The paper itself

Abstract

Glycosylphosphatidylinositol (GPI) anchoring of the prion protein (PrP IMPORTANCE: Mechanisms of prion propagation, and what makes them transmissible, are poorly understood. Glycosylphosphatidylinositol (GPI) membrane anchoring of the prion protein (PrP

Indexed as

Gene ExpressionMembrane MicrodomainsAnimalsCell LineGene Knockout TechniquesMembrane ProteinsMicePrion DiseasesPrionsProtein IsoformsProtein TransportPrPC ProteinsPrPSc ProteinsMembrane ProteinsPrionsProtein IsoformsPrPC ProteinsPrPSc ProteinsGPIneuronNpL2prionPrPrafttransmembranetransmissible spongiform encephalopathy

Identifiers

PMID27847358
PMCPMC5215353
OpenAlexW2556981352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.