Evidence map›Paper›PMID 27847344›Full record

ReviewMethods (San Diego, Calif.)2017

Assessing the effects of threonyl-tRNA synthetase on angiogenesis-related responses.

Adam C Mirando, Khadar Abdi, Peibin Wo, Karen M Lounsbury

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Methods (San Diego, Calif.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Aminoacyl-tRNA synthetases.Methods (San Diego, Calif.) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adam C MirandoDepartment of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405, United States.
Khadar AbdiDepartment of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405, United States.
Peibin WoDepartment of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405, United States.
Karen M LounsburyDepartment of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405, United States. Electronic address: Karen.lounsbury@uvm.edu.

Funding

Structure and Mechanism of Class II tRNA SynthetasesR01GM054899 · NIGMS · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI FRANCKLYN, CHRISTOPHER S · 1997 to 2017
$5.7M
ENVIRONMENTAL PATHOLOGY TRAINING PROGRAMT32ES007122 · NIEHS · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 1985 to 2012
$4.2M
NIEHS NIH HHS T32 ES007122NIGMS NIH HHS R01 GM054899
6 · The paper itself

Abstract

Several recent reports have found a connection between specific aminoacyl-tRNA synthetases and the regulation of angiogenesis. As this new area of research is explored, it is important to have reliable assays to assess the specific angiogenesis functions of these enzymes. This review provides information about specific in vitro and in vivo methods that were used to assess the angiogenic functions of threonyl-tRNA synthetase including endothelial cell migration and tube assays as well as chorioallantoic membrane and tumor vascularization assays. The theory and discussion include best methods of analysis and quantification along with the advantages and limitations of each type of assay.

Indexed as

Biological AssayTransfer RNA AminoacylationAnimalsBiomarkers, TumorCell MovementChick EmbryoChorioallantoic MembraneCollagenDrug CombinationsEnzyme InhibitorsFemaleGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsLamininMiceBiomarkers, TumorCollagenDrug CombinationsEnzyme InhibitorsLamininmatrigelPlatelet Endothelial Cell Adhesion Molecule-1ProteoglycansRecombinant Fusion ProteinsRNA, Small InterferingRNA, Transfer, ThrThreonine-tRNA LigaseAminoacyl-tRNA synthetaseAngiogenesis methodsCAM assayEndothelial cellsImageJMetaMorph

Identifiers

PMID27847344
PMCPMC5292763

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.