SynthesisBMC neurology2016
Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis.
Synthesis in BMC neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
148 citing papers in PubMed, 5 syntheses or guidelines pooled it, 336 citations in OpenAlex.
- Clinical presentation, investigation findings, and outcomes of hypophysitis in sarcoidosis: a systematic review.Pituitary · 2026Pooled it
- Cerebral vasculitis related to neurosarcoidosis: a case series and systematic literature review.Journal of neurology · 2025Pooled it
- Infliximab in neurosarcoidosis: a systematic review and meta-analysis.Annals of clinical and translational neurology · 2024Pooled it
- Neurosarcoidosis in children: A systematic review and summary of cases, imaging and management.Journal of neuroimmunology · 2022Pooled it
- Clinical characteristics and outcome of neurosarcoidosis-associated myelitis: A retrospective cohort study and review of the literature.European journal of neurology · 2022Pooled it
- Article
- Abdominal manifestations of multisystem diseases: a pattern-based imaging review.Abdominal radiology (New York) · 2026Review
- Hypopituitarism Revealing Probable Neurosarcoidosis: A Case Report and Diagnostic Challenges.Reports (MDPI) · 2026Article
- Defining Relapse and Disease Activity in Neurosarcoidosis: A Systematic Review and Proposed Framework.Neurology. Clinical practice · 2026Review
- A case of trigeminal nerve neurosarcoidosis initially presenting with isolated neurological findings mimicking trigeminal schwannoma: a case report and review of the literature.Journal of medical case reports · 2026Review
- Rare Neurosarcoidosis Involvements.Respirology case reports · 2026Article
- Corticosteroids as adjunctive therapy in acute meningitis: a narrative review.Annals of medicine and surgery (2012) · 2026Review
- From the Optic Neuritis Treatment Trial to Antibody-Mediated Optic Neuritis: Four Decades of Progress and Unanswered Questions.Biomedicines · 2026Review
- Unmasking neurosarcoidosis in a patient with acute zonal occult outer retinopathy: a case report.BMC ophthalmology · 2026Article
- Cerebrovascular Manifestations of Neurosarcoidosis - An Overview.Vascular health and risk management · 2026Review
- Contemporary management of sarcoidosis.Frontiers in medicine · 2026Review
- Neuropsychiatric manifestations of sarcoidosis.Annals of medicine · 2025Review
- A Multi-Center Retrospective Cohort Study of Neurosarcoidosis Myelitis: Current Observations and Future Directions.Annals of clinical and translational neurology · 2025Article
- Neurosarcoidosis in Critical Care, Internal, and Pulmonary Medicine: A Practical Approach.Seminars in respiratory and critical care medicine · 2025Review
- Neurosarcoidosis: a review from diagnosis and future perspectives.EClinicalMedicine · 2025Review
88 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNeurosarcoidosis is a rare variant of sarcoidosis and is only described in small cohort studies. We define clinical features, treatment and outcome of patients with neurosarcoidosis over the last 35 years.
methodsWe performed a systematic review and meta-analysis of studies on neurosarcoidosis published between 1980 and 2016. Studies were included if they reported at least 5 cases. Studies describing one specific neurological presentation were excluded.
resultsWe identified 29 articles describing 1088 patients diagnosed between 1965 and 2015. Neurosarcoidosis occurred in 5% of patients with systemic sarcoidosis. Mean age at presentation was 43 years and neurological symptoms were the first clinical manifestation of sarcoidosis in 52%. The most commonly reported feature of neurosarcoidosis was cranial neuropathy in 55%, with the facial and optic nerve most commonly affected, followed by headache in 32%. Pleiocytosis and elevated CSF protein were found in 58 and 63%. MRI of the brain showed abnormalities in 70%. Chest X-ray, chest CT, or gallium-67-scintigraphy showed findings consistent with sarcoidosis in 60%, 70% and 69%, respectively. First line therapy with corticosteroids was initiated in 434 of 539 patients (81%). Second and third line therapy was started in 27 and 9%. Outcome consisted of complete remission in 27%, incomplete remission in 32%, stable disease in 24%, deterioration in 6% and death in 5%.
conclusionNeurosarcoidosis has a heterogeneous clinical presentation and the diagnosis can be difficult because of low sensitivity of ancillary investigations. New treatments have emerged, but nevertheless one third of patients do not respond to treatment. Prospective cohort studies and RCTs on treatment are urgently needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.