Evidence map›Paper›PMID 27846731›Full record

ArticleBrain connectivity2017

Dynamic Connectivity Patterns in Conscious and Unconscious Brain.

Yuncong Ma, Christina Hamilton, Nanyin Zhang

Abstract read
In one paragraph

Article in Brain connectivity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Where do we stand on fMRI in awake mice?Cerebral cortex (New York, N.Y. : 1991) · 2024
    Pooled it
  2. Article
  3. Article
  4. Frontostriatal regulation of brain circuits contributes to flexible decision making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuncong Ma1 Department of Biomedical Engineering, Pennsylvania State University, University Park , Pennsylvania.
Christina Hamilton2 The Huck Institutes of Life Sciences, Pennsylvania State University, University Park , Pennsylvania.
Nanyin Zhang1 Department of Biomedical Engineering, Pennsylvania State University, University Park , Pennsylvania.

Funding

Resting-state Neural Networks in Awake RodentsR01NS085200 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI ZHANG, NANYIN · 2013 to 2024
$3.4M
Longitudinal assessment of trauma on neural circuitry development into adulthoodR01MH098003 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI KING, JEAN A, ZHANG, NANYIN · 2013 to 2017
$1.8M
NIMH NIH HHS R01 MH098003NINDS NIH HHS R01 NS085200
6 · The paper itself

Abstract

Brain functional connectivity undergoes dynamic changes from the awake to unconscious states. However, how the dynamics of functional connectivity patterns are linked to consciousness at the behavioral level remains elusive. In this study, we acquired resting-state functional magnetic resonance imaging data during wakefulness and graded levels of consciousness in rats. Data were analyzed using a dynamic approach combining the sliding window method and k-means clustering. Our results demonstrate that whole-brain networks contained several quasi-stable patterns that dynamically recurred from the awake state into anesthetized states. Remarkably, two brain connectivity states with distinct spatial similarity to the structure of anatomical connectivity were strongly biased toward high and low consciousness levels, respectively. These results provide compelling neuroimaging evidence linking the dynamics of whole-brain functional connectivity patterns and states of consciousness at the behavioral level.

Indexed as

Brain MappingNonlinear DynamicsAnalysis of VarianceAnesthetics, InhalationAnimalsBrainConsciousnessDose-Response Relationship, DrugImage Processing, Computer-AssistedIsofluraneMaleNeural Networks, ComputerNeural PathwaysRatsRats, Long-EvansUnconsciousnessAnesthetics, InhalationIsofluraneanesthetic-induced unconsciousnessdynamic functional connectivityratresting-state networks

Identifiers

PMID27846731
PMCPMC5312592

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.