ArticleScience (New York, N.Y.)2016
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.
Registry-linked trialAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03532438 (Whole Genome Sequencing of Nontuberculous Mycobacterium), which is not on this map. Cited by 318 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
318citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Whole Genome Sequencing of Nontuberculous Mycobacterium (NTM) Derived From Sputum Specimen of NTM Lung Disease Patients Living Together and From Their Environmental Samples
Who cites it
318 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Efficacy and safety of imipenem/cilastatin/relebactam (IMI/CS/REL): a meta-analysis of randomized controlled clinical trials.BMC infectious diseases · 2025Pooled it
- Antibiotic treatment for non-tuberculous mycobacteria lung infection in people with cystic fibrosis.The Cochrane database of systematic reviews · 2025Pooled it
- What do the clinical features of positive nontuberculous mycobacteria isolates from patients with HIV/AIDS in China reveal? A systematic review and meta-analysis.Journal of global health · 2023Pooled it
- Identification and characterization ofMicrobiology spectrum · 2026Article
- A review of tigecycline resistance in nontuberculous mycobacteria.Molecular biology reports · 2026Review
- Phylogenetic distribution and longitudinal persistence of plasmids inMicrobial genomics · 2026Article
- Pulmonary Nontuberculous Mycobacterial Disease in a Tuberculosis-Endemic Setting: Two Cases Illustrating Diagnostic Pitfalls.Reports (MDPI) · 2026Article
- Novel Hawai'i and Pacific Island circulating clusters ofApplied and environmental microbiology · 2026Article
- Article
- Hospital Environment-Associated Sources of Mycobacterium abscessus Infection in Transplant Recipients.JAMA network open · 2026Article
- Pharmacological targeting of the mycothiol cysteine ligase MshC in Mycobacteriumabscessus.The Journal of biological chemistry · 2026Article
- Genetic analysis ofiScience · 2026Article
- Review
- Understanding recurrence inJournal of clinical microbiology · 2026Review
- Lung organoids as a human system for Mycobacteria infection modeling and drug testing.The FEBS journal · 2026Review
- From colonisation to chronicity: adaptation ofMicrobiology (Reading, England) · 2026Article
- Nontuberculous Mycobacterium Peritonitis in Patients on Peritoneal Dialysis: A Scoping Review.Microorganisms · 2026Review
- The Role of β-Lactam Antibiotics in Treating Mycobacterium abscessus: From Laboratory Insights to Clinical Applications and the Case for Clinical Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Review
- Large-scale testing of antimicrobial lethality at single-cell resolution predicts mycobacterial infection outcomes.Nature microbiology · 2026Article
- Article
258 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
81 authors.
Josephine M Bryant *Wellcome Trust Sanger Institute, Hinxton, UK.
Dorothy M Grogono *University of Cambridge Department of Medicine, MRC-Laboratory of Molecular Biology, Cambridge, UK.
Daniela Rodriguez-RinconUniversity of Cambridge Department of Medicine, MRC-Laboratory of Molecular Biology, Cambridge, UK.
Isobel EverallWellcome Trust Sanger Institute, Hinxton, UK.
Karen P BrownUniversity of Cambridge Department of Medicine, MRC-Laboratory of Molecular Biology, Cambridge, UK.
Pablo MorenoEMBL European Bioinformatics Institute, Hinxton, UK.
Deepshikha VermaMycobacteria Research Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins CO, USA.
Emily HillMycobacteria Research Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins CO, USA.
Judith DrijkoningenUniversity of Cambridge Department of Medicine, MRC-Laboratory of Molecular Biology, Cambridge, UK.
Peter GilliganUniversity of North Carolina School of Medicine, NC, USA.
Charles R EstherUniversity of North Carolina School of Medicine, NC, USA.
Peadar G NooneUniversity of North Carolina School of Medicine, NC, USA.
Olivia GiddingsUniversity of North Carolina School of Medicine, NC, USA.
Scott C BellQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Rachel ThomsonGallipoli Medical Research Centre, University of Queensland, Brisbane, Australia.
Claire E WainwrightSchool of Medicine, The University of Queensland, Australia.
Chris CoulterQueensland Mycobacterial Reference Laboratory, Brisbane, Australia.
Sushil PandeyQueensland Mycobacterial Reference Laboratory, Brisbane, Australia.
Michelle E WoodQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Rebecca E StockwellQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Kay A RamsayQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Laura J SherrardQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Timothy J KiddCentre for Experimental Medicine, Queen's University Belfast, UK.
Nassib JabbourQueensland University of Technology, Brisbane, Australia.
Graham R JohnsonInternational Laboratory for Air Quality and Health, Queensland University of Technology, Brisbane, Australia.
Luke D KnibbsSchool of Public Health, The University of Queensland, Brisbane, Australia.
Lidia MorawskaInternational Laboratory for Air Quality and Health, Queensland University of Technology, Brisbane, Australia.
Peter D SlyChild Health Research Centre, The University of Queensland, Brisbane, Australia.
Andrew JonesRoyal Brompton and Harefield NHS Foundation Trust, UK.
Diana BiltonRoyal Brompton and Harefield NHS Foundation Trust, UK.
Ian LaurensonScottish Mycobacteria Reference Laboratory, UK.
Michael RuddyWales Centre for Mycobacteria, UK.
Stephen BourkeThe Newcastle upon Tyne Hospitals NHS Foundation Trust, UK.
Ian Cjw BowlerOxford University Hospitals NHS Foundation Trust, UK.
Stephen J ChapmanOxford University Hospitals NHS Foundation Trust, UK.
Andrew ClaytonNottingham University Hospitals NHS Trust, UK.
Mairi CullenUniversity Hospital of South Manchester NHS Foundation Trust, UK.
Thomas DanielsUniversity Hospital of South Manchester NHS Foundation Trust, UK.
Owen DempseyAberdeen Royal Infirmary, NHS Grampian, Scotland, UK.
Miles DentonThe Leeds Teaching Hospitals NHS Trust, UK.
Maya DesaiBirmingham Children's Hospital NHS Foundation Trust, UK.
Richard J DrewAlder Hey Children's NHS Foundation Trust, UK.
Frank EdenboroughSheffield Teaching Hospitals NHS Foundation Trust, UK.
Jason EvansWales Centre for Mycobacteria, UK.
Jonathan FolbThe Royal Liverpool and Broadgreen University Hospitals NHS Trust, UK.
Helen HumphreyUniversity Hospital Southampton NHS Foundation Trust, UK.
Barbara IsalskaUniversity Hospital of South Manchester NHS Foundation Trust, UK.
Søren Jensen-FangelDepartment of Infectious Diseases, Aarhus University Hospital, Denmark.
Bodil JönssonDepartment of Infectious Medicine, Institute of Biomedicine, University of Gothenburg, Sweden.
Andrew M JonesUniversity Hospital of South Manchester NHS Foundation Trust, UK.
Terese L KatzensteinCopenhagen Cystic Fibrosis Center, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Troels LillebaekInternational reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark.
Gordon MacGregorGartnavel Hospital, Glasgow, NHS Greater Glasgow and Clyde, Scotland, UK.
Sarah MayellAlder Hey Children's NHS Foundation Trust, UK.
Michael MillarBarts Health NHS Trust, London, UK.
Deborah ModhaUniversity Hospitals of Leicester NHS Trust, UK.
Edward F NashHeart of England NHS Foundation Trust, Birmingham, UK.
Christopher O'BrienThe Newcastle upon Tyne Hospitals NHS Foundation Trust, UK.
Deirdre O'BrienSt Vincent's University Hospital, Dublin, Ireland.
Chandra OhriUniversity Hospitals of Leicester NHS Trust, UK.
Caroline S PaoBarts Health NHS Trust, London, UK.
Daniel PeckhamBirmingham Children's Hospital NHS Foundation Trust, UK.
Felicity PerrinKing's College Hospital NHS Foundation Trust, London, UK.
Audrey PerryThe Newcastle upon Tyne Hospitals NHS Foundation Trust, UK.
Tania PresslerCopenhagen Cystic Fibrosis Center, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Laura PrtakThe Royal Liverpool and Broadgreen University Hospitals NHS Trust, UK.
Tavs QvistCopenhagen Cystic Fibrosis Center, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Ali RobbThe Newcastle upon Tyne Hospitals NHS Foundation Trust, UK.
Helen RodgersWestern General Hospital, NHS Lothian, Scotland, UK.
Kirsten SchafferSt Vincent's University Hospital, Dublin, Ireland.
Nadia ShafiCambridge Centre for Lung Infection, Papworth Hospital, Cambridge, UK.
Jakko van IngenDepartment of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Martin WalshawLiverpool Heart and Chest Hospital NHS Foundation Trust, UK.
Danie WatsonBarts Health NHS Trust, London, UK.
Noreen WestSheffield Children's NHS Foundation Trust, UK.
Joanna WhitehouseHeart of England NHS Foundation Trust, Birmingham, UK.
Charles S HaworthCambridge Centre for Lung Infection, Papworth Hospital, Cambridge, UK.
Simon R HarrisWellcome Trust Sanger Institute, Hinxton, UK.
Diane OrdwayMycobacteria Research Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins CO, USA.
Julian ParkhillWellcome Trust Sanger Institute, Hinxton, UK.
R Andres FlotoUniversity of Cambridge Department of Medicine, MRC-Laboratory of Molecular Biology, Cambridge, UK.
Funding
Medical Research Council G1001712Wellcome Trust
Abstract
Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.
Indexed as
Drug Resistance, Multiple, BacterialAnimalsCommunicable Diseases, EmergingCystic FibrosisGenome, BacterialGenomicsHumansIncidenceLungMiceMice, SCIDMycobacterium Infections, NontuberculousNontuberculous MycobacteriaPhylogenyPneumonia, BacterialPolymorphism, Single Nucleotide
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Registered trials
NCT03532438ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.