ReviewScience (New York, N.Y.)2016
Writ large: Genomic dissection of the effect of cellular environment on immune response.
Review in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- BACH1 orchestrates macrophage state transitions to coordinate regenerative inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Investigating the Relationship Between Cortisol, a Stress Marker, and Immune Function Across Age and Gender.Cureus · 2025Article
- Comparative analysis of cell-cell communication at single-cell resolution.Nature biotechnology · 2024Article
- Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast cancer.Nature communications · 2023Article
- Editorial: Genes, diseases, immunity and immunogenomics.Frontiers in genetics · 2023Article
- Functional inference of gene regulation using single-cell multi-omics.Cell genomics · 2022Article
- DestVI identifies continuums of cell types in spatial transcriptomics data.Nature biotechnology · 2022Article
- Anti-IL-8 antibody activates myeloid cells and potentiates the anti-tumor activity of anti-PD-1 antibody in the humanized pancreatic cancer murine model.Cancer letters · 2022Article
- ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis.Nature communications · 2022Article
- How cell migration helps immune sentinels.Frontiers in cell and developmental biology · 2022Review
- Inflammatory Bowel Disease Therapy: Beyond the Immunome.Frontiers in immunology · 2022Article
- Defining lung cancer stem cells exosomal payload of miRNAs in clinical perspective.World journal of stem cells · 2020Review
- NicheNet: modeling intercellular communication by linking ligands to target genes.Nature methods · 2020Article
- Innate B Cells: the Archetype of Protective Immune Cells.Clinical reviews in allergy & immunology · 2020Review
- Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction.Cell stem cell · 2019Article
- Review
- Systems Immunology: Learning the Rules of the Immune System.Annual review of immunology · 2018Review
- Upper Respiratory Symptoms, Gut Health and Mucosal Immunity in Athletes.Sports medicine (Auckland, N.Z.) · 2018Review
- Review
- The Human Cell Atlas.eLife · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Cells of the immune system routinely respond to cues from their local environment and feed back to their surroundings through transient responses, choice of differentiation trajectories, plastic changes in cell state, and malleable adaptation to their tissue of residence. Genomic approaches have opened the way for comprehensive interrogation of such orchestrated responses. Focusing on genomic profiling of transcriptional and epigenetic cell states, we discuss how they are applied to investigate immune cells faced with various environmental cues. We highlight some of the emerging principles on the role of dense regulatory circuitry, epigenetic memory, cell type fluidity, and reuse of regulatory modules in achieving and maintaining appropriate responses to a changing environment. These provide a first step toward a systematic understanding of molecular circuits in complex tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.