Evidence map›Paper›PMID 27846455›Full record

ArticleInternational journal of surgery case reports2016

Case Report of the positive exostosin-1 without B-cell lymphoma-2 gene expression of giant cell tumor lesion in hereditary multiple exostosis.

I Gede Eka Wiratnaya, Nyoman Gede Aditya Gitapradita B, I G N Yudhi Setiawan, I Ketut Suyasa, I Ketut Siki Kawiyana, Putu Astawa

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In one paragraph

Article in International journal of surgery case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

I Gede Eka WiratnayaOrthopaedic Surgeon at Department of Orthopaedic and Traumatology, Medical Faculty, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia. Electronic address: ekawiratnaya@gmail.com.
Nyoman Gede Aditya Gitapradita BOrthopaedic Resident at Department of Orthopaedic and Traumatology, Medical Faculty, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia.
I G N Yudhi SetiawanOrthopaedic Resident at Department of Orthopaedic and Traumatology, Medical Faculty, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia.
I Ketut SuyasaChief of Orthopaedic and Traumatology Department at Sanglah General Hospital, Medical Faculty, Udayana University, Denpasar, Bali, Indonesia.
I Ketut Siki KawiyanaProfessor at Orthopaedic and Traumatology Department at Sanglah General Hospital, Medical Faculty, Udayana University, Denpasar, Bali, Indonesia.
Putu AstawaProfessor at Orthopaedic and Traumatology Department at Sanglah General Hospital, Medical Faculty, Udayana University, Denpasar, Bali, Indonesia.
Rumah Sakit Umum Pusat Sanglah Denpasar · IDUdayana University · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe giant cell tumor, in which BCL-2 gene was expressed only in its malignant transformation, is a benign, primary skeletal neoplasm with variable biologic aggressiveness. The is of the giant cell tumor. A coexistence with hereditary multiple exostosis with expression of EXT-1 is very rare. The correlation between giant cell tumor in hereditary multiple exostosis is still not clearly determined. PRESENTATION OF CASE: A 31-years-old female presented with pain and lump on her left wrist and a coexistence of non tender multiple lump in the right and left knee. A wide excision of the tumor and reconstruction using non vascularized fibular graft was performed, followed by histopathology and immunohistochemistry of EXT-1 and BCL-2. DISCUSSION: In this case, the tumor showed negative BCL-2 and positive EXT-1 gene expression. Giant cell tumor and hereditary multiple exostosis also demonstrated associations of chromosomes 11 with a different pathological process.

conclusionGiant cell tumor in hereditary multiple exostosis revealed positive EXT-1 without BCL-2 expression. It still need more investigation to confirm the relationship between these tumors.

Indexed as

BCL-2 geneCase reportEXT-1 geneGiant cell tumorHereditary multiple exostosis

Identifiers

PMID27846455
PMCPMC5109267
OpenAlexW2552751929

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.