Evidence map›Paper›PMID 27846383›Full record

ArticleCancer cell2016

UNRelenting Translation UNRestrains Melanoma Migration.

Ashani T Weeraratna, Myriam Gorospe

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ashani T WeeraratnaTumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
Myriam GorospeLaboratory of Genetics and Genomics, National Institute on Aging-IRP, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: myriam-gorospe@nih.gov.
National Institutes of Health · USThe Wistar Institute · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Post-transcriptional Regulation Of Proliferative and Stress Response GenesZIAAG000511 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM · 2009 to 2025
$25.4M
Promotion of tumor invasion and pseudosenescence by the aging microenvironmentR01CA174746 · NCI · WISTAR INSTITUTE · PI WEERARATNA, ASHANI T · 2014 to 2018
$2.1M
Intramural NIH HHS ZIA AG000511NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA174746
6 · The paper itself

Abstract

The cytoplasmic RNA-binding protein UNR influences key developmental processes by controlling mRNA turnover and translation initiation. In this issue of Cancer Cell, Wurth et al. report that UNR is highly expressed in melanoma and enhances invasion and metastasis at least partly by inducing translation elongation of VIM and RAC1 mRNAs.

Indexed as

DNA-Binding ProteinsHumansMelanomaProtein BiosynthesisRNA-Binding ProteinsRNA, MessengerDNA-Binding ProteinsRNA-Binding ProteinsRNA, Messenger

Identifiers

PMID27846383
PMCPMC5489341
OpenAlexW2551881034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.