Evidence map›Paper›PMID 27845905›Full record

ArticleOncotarget2016

Distance to Thrombus in acute middle cerebral artery stroke predicts basal ganglia infarction after mechanical thrombectomy.

Benjamin Friedrich, Donald Lobsien, Christian Maegerlein, Silke Wunderlich, Claus Zimmer, Johannes Kaesmacher, Justus Kleine

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Benjamin FriedrichDepartment of diagnostic and interventional Neuroradiology, Klinikum rechts der Isar, Munich, Germany.
Donald LobsienDepartment of Neuroradiology, University Hospital Leipzig, Leipzig, Germany.
Christian MaegerleinDepartment of diagnostic and interventional Neuroradiology, Klinikum rechts der Isar, Munich, Germany.
Silke WunderlichDepartment of Neurology, Klinikum rechts der Isar, Munich, Germany.
Claus ZimmerDepartment of diagnostic and interventional Neuroradiology, Klinikum rechts der Isar, Munich, Germany.
Johannes KaesmacherDepartment of diagnostic and interventional Neuroradiology, Klinikum rechts der Isar, Munich, Germany.
Justus KleineDepartment of diagnostic and interventional Neuroradiology, Klinikum rechts der Isar, Munich, Germany.
Klinikum rechts der Isar · DEUniversity Hospital Leipzig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThis study examines if involvement of the lenticulostriate arteries (LSAs) in MCA stroke and consecutive infarction of the basal ganglia can be predicted by the exact occlusion site, as determined in pre-interventional CT or MRI imaging.

methodsRetrospective analysis of 212 patients with acute isolated MCA occlusions treated with mechanical thrombectomy. The occlusion site was assessed using the Distance to Thrombus (DT). Affection of LSAs by the occlusion was determined by analysis of pre- and post-interventional DSA runs. Infarction of the striatocapsular region was evaluated in post-interventional imaging.

resultsDT showed a highly significant correlation with the affected LSA group (ρ = 0.747; P < 0.001). In a ROC analysis, DT could predict affection of the LSAs with an area under the curve (AUC) of 0.903. Additionally, DT could predict an infarction of the striatocapsular region with an AUC of 0.824. In a stepwise regression analysis for striatocapsular infarction including DT, age, time from symptom onset to recanalization and recanalization success, only DT proved to be an independent predictor.

conclusionIn MCA stroke, the exact site of the occlusion as measured by DT independently predicts the involvement of LSAs and subsequent striatocapsular infarction with high sensitivity and specificity.

Indexed as

AgedAged, 80 and overBasal Ganglia Cerebrovascular DiseaseFemaleHumansInfarction, Middle Cerebral ArteryMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesStrokeThrombectomyTomography, X-Ray Computedbasal gangliadistance to thrombusmechanical thrombectomystroke

Identifiers

PMID27845905
PMCPMC5349876
OpenAlexW2556790346

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.