Evidence map›Paper›PMID 27845796›Full record

ArticleNanoscale2017

Paper microchip with a graphene-modified silver nano-composite electrode for electrical sensing of microbial pathogens.

Mohammadali Safavieh, Vivasvat Kaul, Sultan Khetani, Anupriya Singh, Karan Dhingra, Manoj Kumar Kanakasabapathy, Mohamed Shehata Draz, Adnan Memic, Daniel R Kuritzkes, Hadi Shafiee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Microfluidic devices for detection of RNA viruses.Reviews in medical virology · 2021
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Microbiological Sensing Technologies: A Review.Bioengineering (Basel, Switzerland) · 2018
    Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Mohammadali SafaviehDivision of Engineering in Medicine, Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. hshafiee@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-8929-1902
Vivasvat KaulDivision of Engineering in Medicine, Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. hshafiee@bwh.harvard.edu.
Sultan KhetaniDivision of Engineering in Medicine, Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. hshafiee@bwh.harvard.edu.
Anupriya SinghDivision of Engineering in Medicine, Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. hshafiee@bwh.harvard.edu.
Karan DhingraDivision of Engineering in Medicine, Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. hshafiee@bwh.harvard.edu.
Manoj Kumar KanakasabapathyDivision of Engineering in Medicine, Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. hshafiee@bwh.harvard.edu.
Mohamed Shehata DrazDivision of Engineering in Medicine, Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. hshafiee@bwh.harvard.edu and Faculty of Science, Tanta University, Tanta 31527, Egypt.
Adnan MemicCenter for Nanotechnology, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Daniel R KuritzkesDivision of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA and Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Hadi ShafieeDivision of Engineering in Medicine, Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. hshafiee@bwh.harvard.edu and Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Brigham and Women's Hospital · USKing Abdulaziz University · SA

Funding

Sensitive and quantitative point-of-care viral load testing on paperR01AI118502 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2016 to 2020
$2.2M
NIAID NIH HHS R01 AI118502
6 · The paper itself

Abstract

Rapid and sensitive point-of-care diagnostics are of paramount importance for early detection of infectious diseases and timely initiation of treatment. Here, we present cellulose paper and flexible plastic chips with printed graphene-modified silver electrodes as universal point-of-care diagnostic tools for the rapid and sensitive detection of microbial pathogens or nucleic acids through utilizing electrical sensing modality and loop-mediated isothermal amplification (LAMP). We evaluated the ability of the developed paper-based assay to detect (i) viruses on cellulose-based paper microchips without implementing amplification in samples with viral loads between 10

Indexed as

ElectrodesLab-On-A-Chip DevicesNanocompositesNucleic Acid Amplification TechniquesDNA PrimersGraphiteHIV-1PaperRNA, ViralSensitivity and SpecificitySilverDNA PrimersGraphiteRNA, ViralSilver

Identifiers

PMID27845796
PMCPMC5695240
OpenAlexW2545013763

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.