ReviewMolecules (Basel, Switzerland)2016
The Chemistry and Pharmacology of Citrus Limonoids.
Review in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed, 186 citations in OpenAlex.
- Tissue-Specific Bioactive Metabolites and Antioxidant Activity in Minicitrus (Antioxidants (Basel, Switzerland) · 2026Article
- Time-Resolved Secondary Metabolite Profiling of Seeded and Seedless Ougan at Commercial Harvest Maturity.Current issues in molecular biology · 2026Article
- Distribution and bioactivities of tirucallane-type triterpenoids from Meliaceae family.Natural products and bioprospecting · 2026Review
- NMR-Guided Discovery of Luvunga D: A Novel Propellane-Type Limonoid fromAntioxidants (Basel, Switzerland) · 2026Article
- Compromised blood-brain barrier in traumatic brain injury model ofIranian journal of basic medical sciences · 2026Article
- Holistic valorisation of lemon peel into textile materials via fungal chitosan and micro-nano fibrillated cellulose.Scientific reports · 2025Article
- Phenolic Compounds Accumulation and Cell Death Degree Induced by Fusaric Acid in Agroforestry Hosts Plants ofJournal of fungi (Basel, Switzerland) · 2025Article
- Transcriptome and metabolome profiling of the medicinal plant Dictamnus dasycarpus reveal key genes involved in quinoline alkaloids biosynthesis and limonoids biosynthesis.BMC plant biology · 2025Article
- In vitro antiviral activities of thymol and Limonin against influenza a viruses and SARS-CoV-2.Scientific reports · 2025Article
- Limonin alleviates imiquimod-induced psoriasis-like skin inflammation in mice model by downregulating inflammatory responses.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- A Review on Innovative Biotechnological Approaches for the Upcycling of Citrus Fruit Waste to Obtain Value-Added BioproductsFood technology and biotechnology · 2025Review
- Pesticidal Activity of Citrus Fruits for the Development of Sustainable Fruit-Processing Waste Management and Agricultural Production.Plants (Basel, Switzerland) · 2025Review
- Phytochemicals Controlling EnterohemorrhagicInternational journal of molecular sciences · 2025Review
- Discovery of potent anti-toxoplasmosis drugs from secondary metabolites in Citrus limon (lemon) leaves, supported in-silico study.Scientific reports · 2025Article
- A convergent synthetic approach to the tetracyclic core framework of khayanolide-type limonoids.Beilstein journal of organic chemistry · 2025Article
- Limonin Exhibits Anti-Inflammatory Effects by Inhibiting mTORC1 and Mitochondrial Reactive Oxygen Species in Psoriatic-like Skin Inflammation.Antioxidants (Basel, Switzerland) · 2024Article
- Citrus wastewater as a source of value-added products: Quali-quantitative analysis and in vitro screening on breast cancer cell lines.Archiv der Pharmazie · 2024Article
- Article
- Assessment of the in vitro anti-diabetic activity with molecular dynamic simulations of limonoids isolated from Adalia lemon peels.Scientific reports · 2024Article
- Green Extraction of Plant Materials Using Supercritical COPlants (Basel, Switzerland) · 2024Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach. Synthetic derivatives and other structurally-related limonoids from other sources are include in the analysis. With the focus on literature in the past decade, the chemical classification of CLs, their physico-chemical properties as drugs, their biosynthesis and enzymatic modifications, possible ways of enhancing their biological activities through structural modifications, their ligand efficiency metrics and systematic graphical radar plot analysis to assess their developability as drugs are among those discussed in detail.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.