Evidence map›Paper›PMID 27845754›Full record

ReviewInternational journal of environmental research and public health2016

Secondhand Smoke Is an Important Modifiable Risk Factor in Sickle Cell Disease: A Review of the Current Literature and Areas for Future Research.

S Christy Sadreameli, Benjamin T Kopp, Susan E Creary, Michelle N Eakin, Sharon McGrath-Morrow, John J Strouse

Open access · goldAbstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2017
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

S Christy SadreameliEudowood Division of Pediatric Respiratory Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. ssadrea1@jhmi.edu.
Benjamin T KoppSection of Pediatric Pulmonology, Nationwide Children's Hospital, Columbus, OH 43205, USA. Benjamin.Kopp@nationwidechildrens.org.
Susan E CrearyDivision of Pediatric Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA. Susan.Creary@nationwidechildrens.org.
Michelle N EakinDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. meakin1@jhmi.edu.
Sharon McGrath-MorrowEudowood Division of Pediatric Respiratory Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. smcgrath@jhmi.edu.
John J StrouseDivisions of Hematology and Pediatric Hematology/Oncology, Duke University School of Medicine, Durham, NC 27710, USA. john.strouse@duke.edu.
Johns Hopkins University · USNationwide Children's Hospital · USDuke University · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Resolution of Diffuse Inflammatory Lung Injury in Neonatal MiceR01HL114800 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MCGRATH-MORROW, SHARON ANN · 2013 to 2021
$3.3M
A multidimensional strategy to improve hydroxyurea adherence in children with sickle cellK23HL127303 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI CREARY, SUSAN · 2015 to 2019
$759k
NCATS NIH HHS UL1 TR001079NHLBI NIH HHS K23 HL127303NHLBI NIH HHS R01 HL114800
6 · The paper itself

Abstract

Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy that causes significant morbidity and mortality related to chronic hemolytic anemia, vaso-occlusion, and resultant end-organ damage. Tobacco smoke exposure (TSE) through secondhand smoke exposure in people with SCD of all ages and through primary smoking in adolescents and adults is associated with significantly increased morbidity, with increased rates of emergency department visits and hospitalizations for painful vaso-occlusive crises and acute chest syndrome (ACS). Secondhand smoke is also associated with pulmonary function abnormalities in children with SCD who are already at risk for pulmonary function abnormalities on the basis of SCD. TSE is emerging as one of the few modifiable risk factors of SCD. This review discusses the current state of the evidence with respect to TSE and SCD morbidity, discusses potential mechanisms, and highlights current gaps in the evidence and future research directions.

Indexed as

Anemia, Sickle CellDisease ProgressionHumansLungRisk FactorsTobacco Smoke PollutionTobacco Smoke Pollutionenvironmental tobacco smokepulmonary function testssecondhand smokesickle cell diseasetobacco

Identifiers

PMID27845754
PMCPMC5129341
OpenAlexW2549668407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.