Evidence map›Paper›PMID 27845722›Full record

ArticleToxins2016

Glutathione-Conjugates of Deoxynivalenol in Naturally Contaminated Grain Are Primarily Linked via the Epoxide Group.

Silvio Uhlig, Ana Stanic, Ingerd S Hofgaard, Bernhard Kluger, Rainer Schuhmacher, Christopher O Miles

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
9.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Overlooked and misunderstood: can glutathione conjugates be clues to understanding plant glutathione transferases?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  6. Article
  7. Biocontrol Effect ofPlants (Basel, Switzerland) · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. ModifiedMolecules (Basel, Switzerland) · 2018
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Silvio UhligSection for Chemistry and Toxicology, Norwegian Veterinary Institute, P.O. Box 750 Sentrum, Oslo 0106, Norway. silvio.uhlig@vetinst.no.
Ana StanicSection for Chemistry and Toxicology, Norwegian Veterinary Institute, P.O. Box 750 Sentrum, Oslo 0106, Norway. ana.stanic@vetinst.no.
Ingerd S HofgaardDivision of Biotechnology and Plant Health, NIBIO-Norwegian Institute of Bioeconomy, Høgskoleveien 7, Ås 1430, Norway. ingerd.hofgaard@nibio.no.
Bernhard KlugerCenter for Analytical Chemistry, Department of Agrobiotechnology (IFA-Tulln), University of Natural Resources and Life Sciences, Vienna (BOKU), Tulln 3430, Austria. bernhard.kluger@boku.ac.at.
Rainer SchuhmacherCenter for Analytical Chemistry, Department of Agrobiotechnology (IFA-Tulln), University of Natural Resources and Life Sciences, Vienna (BOKU), Tulln 3430, Austria. rainer.schuhmacher@boku.ac.at.
Christopher O MilesSection for Chemistry and Toxicology, Norwegian Veterinary Institute, P.O. Box 750 Sentrum, Oslo 0106, Norway. chris.miles@vetinst.no.
BOKU University · ATNorwegian Veterinary Institute · NONorwegian Institute of Bioeconomy Research · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A glutathione (GSH) adduct of the mycotoxin 4-deoxynivalenol (DON), together with a range of related conjugates, has recently been tentatively identified by LC-MS of DON-treated wheat spikelets. In this study, we prepared samples of DON conjugated at the 10- and 13-positions with GSH, Cys, CysGly, γ-GluCys and

Indexed as

CysteineEpoxy CompoundsGlutathioneTrichothecenesTriticumCysteinedeoxynivalenolEpoxy CompoundsGlutathioneTrichothecenesbioconjugationHRMSLC-MSmercapturatemetabolismmycotoxinoatsthioltrichothecenewheat

Identifiers

PMID27845722
PMCPMC5127126
OpenAlexW2554265858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.