ArticleJournal of lipid research2017
Differentiating brown and white adipose tissues by high-resolution diffusion NMR spectroscopy.
Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 26 citations in OpenAlex.
- Evaluation of high-fat diet-induced metabolic impairments in iBAT lipid metabolism usingMagma (New York, N.Y.) · 2026Article
- Periodic fasting and refeeding re-shapes lipid saturation, storage, and distribution in brown adipose tissue.PLoS biology · 2026Article
- Characteristics of T2* and anisotropy parameters in inguinal and epididymal adipose tissues after cold exposure in mice.Scientific reports · 2024Article
- MRI-Derived Apparent Diffusion Coefficient of Peri-Prostatic Adipose Tissue Is a Potential Determinant of Prostate Cancer Aggressiveness in Preoperative Setting: A Preliminary Report.International journal of environmental research and public health · 2022Article
- Quantification of brown adipose tissueQuantitative imaging in medicine and surgery · 2022Article
- Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection.Frontiers in endocrinology · 2020Review
- Obesity subtypes, related biomarkers & heterogeneity.The Indian journal of medical research · 2020Review
- Measuring large lipid droplet sizes by probing restricted lipid diffusion effects with diffusion-weighted MRS at 3T.Magnetic resonance in medicine · 2019Article
- The role of adipose tissue in cardiovascular health and disease.Nature reviews. Cardiology · 2019 · on this mapReview
- Non-invasive Imaging Methods for Brown Adipose Tissue Detection and Function Evaluation.Internal medicine: open access · 2018Article
- Potential Application ofScientific reports · 2017Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are two types of fat tissues, white adipose tissue (WAT) and brown adipose tissue (BAT), which essentially perform opposite functions in whole body energy metabolism. There is a large interest in identifying novel biophysical properties of WAT and BAT by a quantitative and easy-to-run technique. In this work, we used high-resolution pulsed field gradient diffusion NMR spectroscopy to study the apparent diffusion coefficient (ADC) of fat molecules in rat BAT and WAT samples. The ADC of fat in BAT and WAT from rats fed with a chow diet was compared with that of rats fed with a high-fat diet to monitor how the diffusion properties change due to obesity-associated parameters such as lipid droplet size, fatty acid chain length, and saturation. Feeding a high-fat diet resulted in increased saturation, increased chain lengths, and reduced ADC of fat in WAT. The ADC of fat was lower in BAT relative to WAT in rats fed both chow and high-fat diets. Diffusion of fat was restricted in BAT due to the presence of small multilocular lipid droplets. Our findings indicate that in vivo diffusion might be a potential way for better delineation of BAT and WAT in both lean and obese states.
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