ArticleScientific reports2016
Odour-induced analgesia mediated by hypothalamic orexin neurons in mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Acute analgesic effect of nicotine vaping using three experimental pain induction tasks: a randomized, placebo-controlled laboratory study.Psychopharmacology · 2025Trial
- Exploring Linalool-Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition.Phytotherapy research : PTR · 2026Review
- Lateral hypothalamic orexinergic neurons as central mediators of pain modulation and non-pharmacological analgesia.Frontiers in pharmacology · 2026Review
- Cannabinoid efficacy for pain: dose, chronicity and route.Frontiers in neuroscience · 2026Review
- Phytochemical Modulators of Nociception: A Review of Cannabis Terpenes in Chronic Pain Syndromes.Pharmaceuticals (Basel, Switzerland) · 2025Review
- A Neural Circuit For Bergamot Essential Oil-Induced Anxiolytic Effects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Possible Combinatorial Utilization of Phytochemicals and Extracellular Vesicles for Wound Healing and Regeneration.International journal of molecular sciences · 2024Review
- AnMini reviews in medicinal chemistry · 2024Article
- Chemical Composition, Analgesic and Anti-Inflammatory Activity ofMolecules (Basel, Switzerland) · 2023Article
- Review
- Hypothalamic orexinergic neurons modulate pain and itch in an opposite way: pain relief and itch exacerbation.The journal of physiological sciences : JPS · 2022Article
- Essential Oils and Neuropathic Pain.Plants (Basel, Switzerland) · 2022Review
- Reciprocal relationships between sleep and smell.Frontiers in neural circuits · 2022Review
- Exploring Pharmacological Mechanisms of Essential Oils on the Central Nervous System.Plants (Basel, Switzerland) · 2021Review
- Analgesic Potential of Terpenes Derived fromPharmacological reviews · 2021Review
- Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia.International journal of molecular sciences · 2021Review
- Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice.Scientific reports · 2021Article
- Linalool odor-induced analgesia is triggered by TRPA1-independent pathway in mice.Behavioral and brain functions : BBF · 2021Article
- History repeats itself: Role of characterizing flavors on nicotine use and abuse.Neuropharmacology · 2020Review
- The Mechanism of Compound Anshen Essential Oil in the Treatment of Insomnia Was Examined by Network Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various folk remedies employ certain odorous compounds with analgesic effects. In fact, linalool, a monoterpene alcohol found in lavender extracts, has been found to attenuate pain responses via subcutaneous, intraperitoneal, intrathecal, and oral administration. However, the analgesic effects of odorous compounds mediated by olfaction have not been thoroughly examined. We performed behavioural pain tests under odourant vapour exposure in mice. Among six odourant molecules examined, linalool significantly increased the pain threshold and attenuated pain behaviours. Olfactory bulb or epithelium lesion removed these effects, indicating that olfactory sensory input triggered the effects. Furthermore, immunohistochemical analysis revealed that linalool activated hypothalamic orexin neurons, one of the key mediators for pain processing. Formalin tests in orexin neuron-ablated and orexin peptide-deficient mice showed orexinergic transmission was essential for linalool odour-induced analgesia. Together, these findings reveal central analgesic circuits triggered by olfactory input in the mammalian brain and support a potential therapeutic approach for treating pain with linalool odour stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.