ArticleScientific reports2016
Psychiatric and neurological disorders are associated with bullous pemphigoid - a nationwide Finnish Care Register study.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Association between bullous pemphigoid and hypertension: a systematic review and meta-analysis of observational studies.Journal of human hypertension · 2025Pooled it
- Pooled it
- Comorbidity in bullous pemphigoid: up-date and clinical implications.Frontiers in immunology · 2023Pooled it
- Associations Between Non-neurological Autoimmune Disorders and Psychosis: A Meta-analysis.Biological psychiatry · 2019Pooled it
- Serum BP180 and BP230 autoantibodies in Alzheimer's disease: diagnostic and cognitive associations in a retrospective study.Frontiers in aging neuroscience · 2026Article
- Review
- Bullous pemphigoid.Nature reviews. Disease primers · 2025Review
- Associated factors related to production of autoantibodies and dermo-epidermal separation in bullous pemphigoid.Archives of dermatological research · 2025Review
- From Psychiatric Care to Dermatologic Dilemmas: A Case Report of Risperidone-Induced Bullous Pemphigoid.Cureus · 2024Article
- Skin-brain axis in Alzheimer's disease - Pathologic, diagnostic, and therapeutic implications: A Hypothetical Review.Aging and disease · 2024Review
- Pemphigus and pemphigoid are associated with Alzheimer's disease in older adults: evidence from the US Nationwide inpatient sample 2016-2018.BMC geriatrics · 2023Article
- Accurate diagnosis of bullous pemphigoid requires multiple health care visits.Frontiers in immunology · 2023Article
- Bullous pemphigoid in a patient with a neuropsychological disorder and a possible novel drug trigger: A case report and review of the literature.Skin health and disease · 2022Review
- Recalcitrant bullous pemphigoid responsive to dupilumab in an adolescent patient.JAAD case reports · 2022Article
- Severe bullous pemphigoid with excoriation disorder.BMJ case reports · 2022Article
- Deciphering the Contribution of BP230 Autoantibodies in Bullous Pemphigoid.Antibodies (Basel, Switzerland) · 2022Review
- Comorbidities in Patients with Autoimmune Bullous Disorders: Hospital-Based Registry Study.Life (Basel, Switzerland) · 2022Article
- Evaluation of the toxicity of glucocorticoids in patients with autoimmune blistering disease using the Glucocorticoid Toxicity Index: A cohort study.JAAD international · 2022Article
- The significance of preclinical anti-BP180 autoantibodies.Frontiers in immunology · 2022Review
- Bullous pemphigoid: An immune disorder related to aging (Review).Experimental and therapeutic medicine · 2022Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bullous pemphigoid (BP) is an autoimmune blistering skin disease with increasing incidence. BP is associated with neurological disorders, but it has not been established, what subtypes of dementia and stroke are associated with BP, and what is the temporal relation between these diseases. Also, the association between BP and psychiatric disorders is controversial. We conducted a retrospective nationwide study, using the Finnish Care Register for Health Care diagnoses between 1987 and 2013. The study population of 4524 BP patients were compared with 66138 patients with basocellular carcinoma (BCC), neurological and psychiatric comorbid disorders were evaluated for both groups, and associations were estimated by Cox regression and logistic regression analyses. The strongest risk of developing BP was found after diagnosis of multiple sclerosis (MS) (OR=5.9, 95% CI 3.9-8.5). Among psychiatric diseases, the corresponding risk was strongest in schizophrenia (OR=2.7, 95% CI 2.0-3.5), and as a novel finding, also personality disorders (OR=2.2, 95% CI 1.3-3.3) preceded BP. In conclusion, many psychiatric disorders, especially schizophrenia, carry heightened risk for BP. Furthermore, several neurological diseases which cause central nervous system inflammation or degeneration were related to BP, and the association was strongest between MS and BP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.