ArticleScientific reports2016
Terahertz molecular resonance of cancer DNA.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 178 citations in OpenAlex.
- Dual-band graphene-based THz MIMO antenna for 6G-enabled biomedical application using supervised regression machine learning validation.Scientific reports · 2026Article
- DNA as a quantum system in evolution.PloS one · 2026Article
- Manipulating terahertz phonon-polariton in the ultrastrong coupling regime with bound states in the continuum.Light, science & applications · 2025Article
- Towards autonomous robotic THz-based in vivo skin sensing: the PicoBot.Scientific reports · 2025Article
- Advances in Terahertz Biophysics and Chemistry.Research (Washington, D.C.) · 2025Review
- Study on the detection method of biological characteristics of hepatoma cells based on terahertz time-domain spectroscopy.Biomedical optics express · 2023Article
- Holographic THz Beam Generation by Nonlinear Plasmonic Metasurface Emitters.ACS photonics · 2023Article
- Spatial and spectral characteristics in realizations of broadband terahertz spectroscopy on a subwavelength scale.Scientific reports · 2023Article
- Investigating the function and design of molecular materials through terahertz vibrational spectroscopy.Nature reviews. Chemistry · 2023Review
- Terahertz Nonlinear Ghost Imaging via Plane Decomposition: Toward Near-Field Micro-Volumetry.ACS photonics · 2023Article
- Exploring the Application of Multi-Resonant Bands Terahertz Metamaterials in the Field of Carbohydrate Films Sensing.Biosensors · 2023Article
- Epigenetic modification of gene expression in cancer cells by terahertz demethylation.Scientific reports · 2023Article
- Review
- Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts.International journal of molecular sciences · 2023Review
- [Research Progress in the Application of Terahertz Spectroscopy and Imaging Technology in Stomatology].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Review
- Terahertz Kerr Effect of Liquids.Sensors (Basel, Switzerland) · 2022Review
- Spectral Response and Wavefront Control of a C-Shaped Fractal Cadmium Telluride/Silicon Carbide Metasurface in the THz Bandgap.Materials (Basel, Switzerland) · 2022Article
- Dielectric dispersion characteristics of the phospholipid bilayer with subnanometer resolution from terahertz to mid-infrared.Frontiers in bioengineering and biotechnology · 2022Article
- Detection of Lung Cancer Cells in Solutions Using a Terahertz Chemical Microscope.Sensors (Basel, Switzerland) · 2021Article
- Cellular effects of terahertz waves.Journal of biomedical optics · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carcinogenesis involves the chemical and structural alteration of biomolecules in cells. Aberrant methylation of DNA is a well-known carcinogenic mechanism and a common chemical modification of DNA. Terahertz waves can directly observe changes in DNA because the characteristic energies lie in the same frequency region. In addition, terahertz energy levels are not high enough to damage DNA by ionization. Here, we present terahertz molecular resonance fingerprints of DNA methylation in cancer DNA. Methylated cytidine, a nucleoside, has terahertz characteristic energies that give rise to the molecular resonance of methylation in DNA. Molecular resonance is monitored in aqueous solutions of genomic DNA from cancer cell lines using a terahertz time-domain spectroscopic technique. Resonance signals can be quantified to identify the types of cancer cells with a certain degree of DNA methylation. These measurements reveal the existence of molecular resonance fingerprints of cancer DNAs in the terahertz region, which can be utilized for the early diagnosis of cancer cells at the molecular level.
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