ArticleScientific reports2016
A genomic island in Vibrio cholerae with VPI-1 site-specific recombination characteristics contains CRISPR-Cas and type VI secretion modules.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- The type VI secretion system and associated effector proteins.Nature reviews. Microbiology · 2026Review
- Structural basis of Cas8-independent Cas3 recruitment in Type I-F2 CRISPR-Cas.Nucleic acids research · 2026Article
- CholeraSeq: a comprehensive genomic pipeline for cholera surveillance and near real-time outbreak investigation.Bioinformatics (Oxford, England) · 2026Article
- Lineage-restricted genomic islands drive rhizosphere niche specialization inISME communications · 2026Article
- Genomic insights into clinical non-O1/non-O139Microbiology spectrum · 2025Article
- Exploring Mobile Genetic Elements in Vibrio cholerae.Genome biology and evolution · 2025Article
- PandemicLife science alliance · 2023Article
- Type VI Secretion Systems: Environmental and Intra-host Competition of Vibrio cholerae.Advances in experimental medicine and biology · 2023Article
- Article
- Role of Bacteriophages in the Evolution of Pathogenic Vibrios and Lessons for Phage Therapy.Advances in experimental medicine and biology · 2023Article
- Genomic dissection of theMicrobial genomics · 2022Article
- CRISPR-Cas systems target endogenous genes to impact bacterial physiology and alter mammalian immune responses.Molecular biomedicine · 2022Review
- CRISPR-Cas systems are present predominantly on chromosome and its relationship with MEGs in Vibrio species.Archives of microbiology · 2021Article
- AMicrobial genomics · 2021Article
- A New Contact Killing Toxin Permeabilizes Cells and Belongs to a Broadly Distributed Protein Family.mSphere · 2021Article
- Population Analysis of Vibrio cholerae in Aquatic Reservoirs Reveals a Novel Sister Species (Applied and environmental microbiology · 2021Article
- Virulence and Antibiotic Resistance Characteristics ofFrontiers in cellular and infection microbiology · 2021Article
- Modular Molecular Weaponry Plays a Key Role in Competition Within an EnvironmentalFrontiers in microbiology · 2021Article
- Pandemic Vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism.Nature communications · 2020Article
- Interbacterial competition and anti-predatory behaviour of environmental Vibrio cholerae strains.Environmental microbiology · 2020Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
Cholera is a devastating diarrhoeal disease caused by certain strains of serogroup O1/O139 Vibrio cholerae. Mobile genetic elements such as genomic islands (GIs) have been pivotal in the evolution of O1/O139 V. cholerae. Perhaps the most important GI involved in cholera disease is the V. cholerae pathogenicity island 1 (VPI-1). This GI contains the toxin-coregulated pilus (TCP) gene cluster that is necessary for colonization of the human intestine as well as being the receptor for infection by the cholera-toxin bearing CTX phage. In this study, we report a GI (designated GIVchS12) from a non-O1/O139 strain of V. cholerae that is present in the same chromosomal location as VPI-1, contains an integrase gene with 94% nucleotide and 100% protein identity to the VPI-1 integrase, and attachment (att) sites 100% identical to those found in VPI-1. However, instead of TCP and the other accessory genes present in VPI-1, GIVchS12 contains a CRISPR-Cas element and a type VI secretion system (T6SS). GIs similar to GIVchS12 were identified in other V. cholerae genomes, also containing CRISPR-Cas elements and/or T6SS's. This study highlights the diversity of GIs circulating in natural V. cholerae populations and identifies GIs with VPI-1 recombination characteristics as a propagator of CRISPR-Cas and T6SS modules.
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