Evidence map›Paper›PMID 27845338›Full record

Trial reportThe American journal of gastroenterology2017

Internet-Delivered Cognitive Behavior Therapy for Adolescents With Irritable Bowel Syndrome: A Randomized Controlled Trial.

Marianne Bonnert, Ola Olén, Maria Lalouni, Marc A Benninga, Matteo Bottai, Johanna Engelbrektsson, Erik Hedman, Fabian Lenhard, Bo Melin, Magnus Simrén and 3 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The American journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 5 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 5 syntheses or guidelines pooled it, 148 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Marianne BonnertDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden.
Ola OlénDepartment of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Maria LalouniStockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Marc A BenningaDepartment of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital/Academic Medical Centre, Amsterdam, The Netherlands.
Matteo BottaiUnit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Johanna EngelbrektssonStockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Erik HedmanDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden.
Fabian LenhardStockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Bo MelinDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden.
Magnus SimrénDepartment of Internal Medicine & Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Sarah VigerlandStockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Eva SerlachiusStockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Brjánn LjótssonDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SEEmma Kinderziekenhuis · NLMotility (United States) · USStockholm County Council · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesFew treatments have been able to effectively manage pediatric irritable bowel syndrome (IBS). Internet-delivered cognitive behavior therapy (Internet-CBT) based on exposure for abdominal symptoms is effective for adult IBS. The objective of this study was to evaluate the efficacy of Internet-CBT based on behavioral exposure for adolescents with IBS.

methodsAdolescents with IBS fulfilling the Rome III criteria were randomized to either Internet-CBT or a wait-list control. The Internet-CBT was a 10-week intervention where the main component was exposure to IBS symptoms by reduction of avoidance of abdominal symptoms and instead stepwise provocation of symptoms. The primary outcome was total score on Gastrointestinal Symptoms Rating Scale for IBS (GSRS-IBS). Secondary outcomes included adolescent- and parent-rated quality of life and parent-rated gastrointestinal symptoms. Difference between groups was assessed from pretreatment to posttreatment and the Internet-CBT group was also evaluated at 6 months after treatment completion.

resultsA total of 101 adolescents with IBS (13-17 years of age) were included in this study. Dropout rates were low (6%) and all randomized patients were included in intent-to-treat analyses based on mixed effects models. Analyses showed a significant larger pretreatment to posttreatment change on the primary outcome GSRS-IBS (B=-6.42, P=0.006, effect size Cohen's d=0.45, 95% confidence interval (0.12, 0.77)) and on almost all secondary outcomes for the Internet-CBT group compared with the control group. After 6 months, the results were stable or significantly improved.

conclusionsInternet-CBT based on exposure exercises for adolescents with IBS can effectively improve gastrointestinal symptoms and quality of life.

Indexed as

InternetAdolescentCognitive Behavioral TherapyConstipationDiarrheaFemaleHumansIrritable Bowel SyndromeMaleQuality of LifeSeverity of Illness IndexTherapy, Computer-AssistedTreatment Outcome

Identifiers

PMID27845338
OpenAlexW2549844201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.