ArticleNature communications2016
Boosting functionality of synthetic DNA circuits with tailored deactivation.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Continuously tunable multistability in DNA replication networks.Nature communications · 2026Article
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- Bistable Functions and Signaling Motifs in Systems Chemistry: Taking the Next Step Toward Synthetic Cells.Accounts of chemical research · 2025Review
- Robust Sequence Design Space for the Isothermal Exponential Amplification of Short Oligonucleotides.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Functional analysis of single enzymes combining programmable molecular circuits with droplet-based microfluidics.Nature nanotechnology · 2024Article
- Coupling Exponential to Linear Amplification for Endpoint Quantitative Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- DNA as a universal chemical substrate for computing and data storage.Nature reviews. Chemistry · 2024Review
- DNA Reaction System That Acquires Classical Conditioning.ACS synthetic biology · 2024Article
- ANCA: artificial nucleic acid circuit with argonaute protein for one-step isothermal detection of antibiotic-resistant bacteria.Nature communications · 2023Article
- PhotocleavableChemical reviews · 2023Review
- Dynamic Catalysis Guided by Nucleic Acid Networks and DNA Nanostructures.Bioconjugate chemistry · 2023Review
- Standardized excitable elements for scalable engineering of far-from-equilibrium chemical networks.Nature chemistry · 2022Article
- Autoinhibited transient, gated, and cascaded dynamic transcription of RNAs.Science advances · 2022Article
- Cascaded dissipative DNAzyme-driven layered networks guide transient replication of coded-strands as gene models.Nature communications · 2022Article
- Programmable synthetic cell networks regulated by tuneable reaction rates.Nature communications · 2022Article
- Memory, switches, and an OR-port through bistability in chemically fueled crystals.Nature communications · 2022Article
- Gated Transient Dissipative Dimerization of DNA Tetrahedra Nanostructures for Programmed DNAzymes Catalysis.ACS nano · 2022Article
- Programmed mechano-chemical coupling in reaction-diffusion active matter.Science advances · 2021Article
- DNAzyme- and light-induced dissipative and gated DNA networks.Chemical science · 2021Article
- A small-molecule chemical interface for molecular programs.Nucleic acids research · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular programming takes advantage of synthetic nucleic acid biochemistry to assemble networks of reactions, in vitro, with the double goal of better understanding cellular regulation and providing information-processing capabilities to man-made chemical systems. The function of molecular circuits is deeply related to their topological structure, but dynamical features (rate laws) also play a critical role. Here we introduce a mechanism to tune the nonlinearities associated with individual nodes of a synthetic network. This mechanism is based on programming deactivation laws using dedicated saturable pathways. We demonstrate this approach through the conversion of a single-node homoeostatic network into a bistable and reversible switch. Furthermore, we prove its generality by adding new functions to the library of reported man-made molecular devices: a system with three addressable bits of memory, and the first DNA-encoded excitable circuit. Specific saturable deactivation pathways thus greatly enrich the functional capability of a given circuit topology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.