ReviewNeuroscience letters2017
Circuit dysregulation and circuit-based treatments in posttraumatic stress disorder.
Review in Neuroscience letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06036511 (Connectivity Changes Associated With Ketamine Assisted Psychotherapy for PTSD), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Connectivity Changes Associated With Ketamine Assisted Psychotherapy for PTSD
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Post-Traumatic Stress Disorder after Civilian Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Prevalence Rates.Journal of neurotrauma · 2019Pooled it
- Increased top-down control of emotions during symptom provocation working memory tasks following a RCT of alpha-down neurofeedback in PTSD.NeuroImage. Clinical · 2023Trial
- Neuroimaging correlates and predictors of response to repeated-dose intravenous ketamine in PTSD: preliminary evidence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Associations between resting-state functional connectivity and treatment response in a randomized clinical trial for posttraumatic stress disorder.Depression and anxiety · 2020Trial
- Neural correlates of emotional reactivity and regulation associated with treatment response in a randomized clinical trial for posttraumatic stress disorder.Psychiatry research. Neuroimaging · 2020Trial
- Theta-Burst Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder.The American journal of psychiatry · 2019Trial
- Innovating transcranial magnetic stimulation treatment for post-traumatic stress disorder: Zapping away the bad memory.Fundamental research · 2025Review
- Enhancing Agency in Posttraumatic Stress Disorder Therapies Through Sensorimotor Technologies.Journal of medical Internet research · 2024Article
- Endocannabinoid release at ventral hippocampal-amygdala synapses regulates stress-induced behavioral adaptation.Cell reports · 2023Article
- Resting-state connectivity subtype of comorbid PTSD and alcohol use disorder moderates improvement from integrated prolonged exposure therapy in Veterans.Psychological medicine · 2023Article
- The role of BDNF in mediating the prophylactic effects of (R,S)-ketamine on fear generalization and extinction.Translational psychiatry · 2022Article
- Fabp7 Is Required for Normal Sleep Suppression and Anxiety-Associated Phenotype following Single-Prolonged Stress in Mice.Neuroglia (Basel, Switzerland) · 2022Article
- Changes in Brain Volume Associated with Trauma-Focused Cognitive Behavioral Therapy Among Youth with Posttraumatic Stress Disorder.Journal of traumatic stress · 2021Article
- Altered resting-state functional connectivity of the default mode and central executive networks following cognitive processing therapy for PTSD.Behavioural brain research · 2021Article
- Neural correlates of conceptual-level fear generalization in posttraumatic stress disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- D-Serine as the gatekeeper of NMDA receptor activity: implications for the pharmacologic management of anxiety disorders.Translational psychiatry · 2020Review
- Dysregulation of inflammation, neurobiology, and cognitive function in PTSD: an integrative review.Cognitive, affective & behavioral neuroscience · 2020Review
- Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice.Molecular psychiatry · 2020Article
- Interaction of Temporal Lobe Epilepsy and Posttraumatic Stress Disorder: Network Analysis of a Single Case.Frontiers in psychology · 2020Article
- Longitudinal changes in brain function associated with symptom improvement in youth with PTSD.Journal of psychiatric research · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Posttraumatic stress disorder (PTSD) is a psychiatric disorder that develops in some individuals in the aftermath of exposure to traumatic events, such as actual or threatened death, serious injury or sexual assault. It has been hypothesized that dysregulations in a number of specific neurocircuits, characterized by heightened responsivity of amygdala, dACC and insula, diminished responsivity of mPFC, impaired hippocampal function and deficits in cortical regions, underlie the development and expression of key PTSD symptoms. Here, we concisely describe three functional neural circuits implicated in PTSD pathophysiology and briefly review selected treatment strategies in the context of these neural circuits. We start with the commonly implicated neurocircuit model, namely, the fear learning and threat detection circuits, and then discuss the context processing circuitry, which plays an important role among others, in fear regulation. We then discuss the emotion regulation circuitry, which can further contribute to PTSD pathophysiology, and conclude with a discussion of the therapeutic approaches that might be targeting dysregulation in these circuits in PTSD patients. Specifically, we discuss how exposure-based treatments might be targeting fear learning circuits, and the pharmacological and brain-stimulation interventions aimed to augment these therapies. Finally, we discuss other pharmacological and cognitive therapeutic approaches that can augment or restore the function of the context processing and emotional regulation circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.