ReviewProgress in biophysics and molecular biology2016
Transmural gradients of myocardial structure and mechanics: Implications for fiber stress and strain in pressure overload.
Review in Progress in biophysics and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Spatial imprints of emergent cardiomyocyte states in the pressure-overloaded heart.bioRxiv : the preprint server for biology · 2026Article
- Modifying the structural substrate and progression of heart failure with preserved ejection fraction using a regular exercise regimen in pigs.American journal of physiology. Heart and circulatory physiology · 2026Article
- Role and Mechanism of Lamellar Derived Growth Factor /AKT Pathway in Ventricular Remodeling Induced by Pressure Overload.Cell biochemistry and biophysics · 2025Article
- Understanding heterogeneous mechanisms of heart failure with preserved ejection fraction through cardiorenal mathematical modeling.PLoS computational biology · 2023Article
- Torsional and strain dysfunction precede overt heart failure in a mouse model of dilated cardiomyopathy pathogenesis.American journal of physiology. Heart and circulatory physiology · 2023Article
- Robust and efficient fixed-point algorithm for the inverse elastostatic problem to identify myocardial passive material parameters and the unloaded reference configuration.Journal of computational physics · 2022Article
- Recreating the heart's helical structure-function relationship with focused rotary jet spinning.Science (New York, N.Y.) · 2022Article
- Cellular and Engineered Organoids for Cardiovascular Models.Circulation research · 2022Review
- A computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation.Computer methods in applied mechanics and engineering · 2021Article
- Novel Methodology for Measuring Regional Myocardial Efficiency.IEEE transactions on medical imaging · 2021Article
- An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload.Scientific reports · 2021Article
- Transmural Distribution of Coronary Perfusion and Myocardial Work Density Due to Alterations in Ventricular Loading, Geometry and Contractility.Frontiers in physiology · 2021Article
- Mechanical stimuli for left ventricular growth during pressure overload.Experimental mechanics · 2021Article
- Angiotensin Receptor-Neprilysin Inhibition Attenuates Right Ventricular Remodeling in Pulmonary Hypertension.Journal of the American Heart Association · 2020Article
- Regional variations in ex-vivo diffusion tensor anisotropy are associated with cardiomyocyte remodeling in rats after left ventricular pressure overload.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Article
- Stretch your heart-but not too far: The role of titin mutations in dilated cardiomyopathy.The Journal of thoracic and cardiovascular surgery · 2018Review
- Effect of Aqueous Extract fromEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study.BioMed research international · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Although a truly complete understanding of whole heart activation, contraction, and deformation is well beyond our current reach, a significant amount of effort has been devoted to discovering and understanding the mechanisms by which myocardial structure determines cardiac function to better treat patients with cardiac disease. Several experimental studies have shown that transmural fiber strain is relatively uniform in both diastole and systole, in contrast to predictions from traditional mechanical theory. Similarly, mathematical models have largely predicted uniform fiber stress across the wall. The development of this uniform pattern of fiber stress and strain during filling and ejection is due to heterogeneous transmural distributions of several myocardial structures. This review summarizes these transmural gradients, their contributions to fiber mechanics, and the potential functional effects of their remodeling during pressure overload hypertrophy.
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