Evidence map›Paper›PMID 27844413›Full record

ArticleJournal of endocrinological investigation2017

Relationship between circulating anti-thyroglobulin antibodies (TgAb) and tumor metabolism in patients with differentiated thyroid cancer (DTC): prognostic implications.

S Morbelli, G Ferrarazzo, E Pomposelli, F Pupo, G Pesce, I Calamia, F Fiz, A Clapasson, M Bauckneht, M Minuto and 3 more

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In one paragraph

Article in Journal of endocrinological investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  12. Intermittent Dosing of Dabrafenib and Trametinib in Metastatic BRAFThyroid : official journal of the American Thyroid Association · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

S MorbelliNuclear Medicine UnitIRCCS AOU San Martino - IST, University of Genoa, Largo R. Benzi 10, 16132, Genoa, Italy. Silviadaniela.morbelli@hsanmartino.it.
G FerrarazzoNuclear Medicine UnitIRCCS AOU San Martino - IST, University of Genoa, Largo R. Benzi 10, 16132, Genoa, Italy.
E PomposelliNuclear Medicine UnitIRCCS AOU San Martino - IST, University of Genoa, Largo R. Benzi 10, 16132, Genoa, Italy.
F PupoAutoimmunity UnitIRCCS AOU San Martino - IST, University of Genoa, Genoa, Italy.
G PesceAutoimmunity UnitIRCCS AOU San Martino - IST, University of Genoa, Genoa, Italy.
I CalamiaNuclear Medicine UnitIRCCS AOU San Martino - IST, University of Genoa, Largo R. Benzi 10, 16132, Genoa, Italy.
F FizNuclear Medicine UnitIRCCS AOU San Martino - IST, University of Genoa, Largo R. Benzi 10, 16132, Genoa, Italy.
A ClapassonAutoimmunity UnitIRCCS AOU San Martino - IST, University of Genoa, Genoa, Italy.
M BaucknehtNuclear Medicine UnitIRCCS AOU San Martino - IST, University of Genoa, Largo R. Benzi 10, 16132, Genoa, Italy.
M MinutoU.O. Chirurgia 1, Department of Surgery, IRCCS AOU San Martino - IST, Genoa, Italy.
G SambucetiNuclear Medicine UnitIRCCS AOU San Martino - IST, University of Genoa, Largo R. Benzi 10, 16132, Genoa, Italy.
M GiustiEndocrinology UnitIRCCS AOU San Martino - IST, University of Genoa, Genoa, Italy.
M BagnascoAutoimmunity UnitIRCCS AOU San Martino - IST, University of Genoa, Genoa, Italy.
Ospedale Policlinico San Martino · ITUniversity of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTgAb have been proposed as tumor markers in DTC. Recent evidence links TgAb levels with DTC aggressiveness. We aimed to evaluate the relationship between TgAb and tumor glucose metabolism in DTC patients.

methodsSeventy-one DTC patients who underwent

resultsSUVmean was significantly higher in Inc-TgAb with respect to Dec-TgAb subgroup (5.2 ± 1.5 vs. 2.9 ± 1.1, p < 0.05). TgAb were higher only in the ED PET+/131I+ subgroup with respect to NED patients (p < 0.01).

conclusionsThe relationship between higher tumor metabolism and trend of TgAb supports a prognostic relevance of TgAb in DTC patients. Significantly higher TgAb in radioiodine avid tumors with positive

Indexed as

AdenocarcinomaAdenocarcinoma, FollicularAdultAgedAged, 80 and overAutoantibodiesBiomarkers, TumorCarcinoma, PapillaryFemaleFluorodeoxyglucose F18HumansLymphatic MetastasisMaleMiddle AgedPositron Emission Tomography Computed TomographyPrognosisanti-thyroglobulinAutoantibodiesBiomarkers, TumorFluorodeoxyglucose F18ThyroglobulinAnti-thyroglobulin autoantibodiesPositron emission tomographyThyroglobulinThyroid Cancer

Identifiers

PMID27844413
OpenAlexW2550095765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.