Evidence map›Paper›PMID 27844409›Full record

ArticleHead and neck pathology2017

Expression of Kallikrein-Related Peptidase 6 in Primary Mucosal Malignant Melanoma of the Head and Neck.

Julia Thierauf, Johannes A Veit, Jochen K Lennerz, Stephanie E Weissinger, Annette Affolter, Johannes Döscher, Christoph Bergmann, Andreas Knopf, Jennifer Grünow, Lisa Grünmüller and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Impairment of SK-MEL-28 Development-A Human Melanoma Cell Line-By theInternational journal of molecular sciences · 2023
    Article
  2. Kallikreins emerge as new regulators of viral infections.Cellular and molecular life sciences : CMLS · 2021
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Julia ThieraufDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany. Julia.thierauf@uniklinik-ulm.de.ORCID http://orcid.org/0000-0002-9607-3866
Johannes A VeitDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
Jochen K LennerzInstitute of Pathology, University Medical Center Ulm, Ulm, Germany.
Stephanie E WeissingerInstitute of Pathology, University Medical Center Ulm, Ulm, Germany.
Annette AffolterSection Experimental and Translational Head and Neck Oncology, Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Heidelberg, Heidelberg, Germany.
Johannes DöscherDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
Christoph BergmannDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Essen, Essen, Germany.
Andreas KnopfDepartment of Otolaryngology, Head and Neck Surgery, Technical University Hospital Munich, Munich, Germany.
Jennifer GrünowSection Experimental and Translational Head and Neck Oncology, Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Heidelberg, Heidelberg, Germany.
Lisa GrünmüllerInstitute of Pathology, University Medical Center Ulm, Ulm, Germany.
Cornelia MauchDepartment of Dermatology and Venerology, University Medical Center of Cologne, Cologne, Germany.
Peter K PlinkertSection Experimental and Translational Head and Neck Oncology, Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Heidelberg, Heidelberg, Germany.
Thomas K HoffmannDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
Jochen HessSection Experimental and Translational Head and Neck Oncology, Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Heidelberg, Heidelberg, Germany.
Heidelberg University · DEUniversity Hospital Ulm · DEEssen University Hospital · DEGerman Cancer Research Center · DEMassachusetts General Hospital · USUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucosal melanomas of the head and neck (MMHN) are aggressive tumors with poor prognosis, different opposed to cutaneous melanoma. In this study, we characterized primary mucosal malignant melanoma for the expression of Kallikrein-related peptidase 6 (KLK6), a member of the KLK family with relevance to the malignant phenotype in various cancer types including cutaneous melanoma. Paraffin-embedded MMHN of 22 patients were stained immunohistochemically for KLK6 and results were correlated with clinical and pathological data. In 77.3% (17/22) of MMHN cases, positive KLK6 staining was found. Staining pattern for tumor cells showed a predominant cytoplasmic staining. However, in six cases we also observed a prominent nuclear staining. MMHN with a high KLK6 expression showed significantly better outcome concerning local recurrence-free survival (p = 0.013) and nuclear KLK6 staining was significantly associated with the survival status (p = 0.027). Overexpression of KLK6 was detected in more than 70% of MMHN and approximately 40% of tumors showed a strong expression pattern. Correlation between clinical outcome of MMHN patients and overexpression of KLK6 has not been addressed so far. Our data demonstrate for the first time increased levels of KLK6 in MMHN and strengthen the hypothesis that there might be a context-specific regulation and function of KLK6 in mucosal melanoma.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorDisease-Free SurvivalFemaleHead and Neck NeoplasmsHumansKallikreinsKaplan-Meier EstimateMaleMelanomaMiddle AgedMucous MembranePrognosisBiomarkers, TumorKallikreinsKLK6 protein, humanHead and neck cancerKallikrein-related peptidase 6KLK6Mucosal melanoma

Identifiers

PMID27844409
PMCPMC5550389
OpenAlexW2552040867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.