ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2016
Chronic hepatitis C virus infection in India: Regional demographics and distribution of viral genotypes.
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Circulation of an atypical hepatitis C virus (HCV) strain at a dialysis unit in northeast India.MicrobiologyOpen · 2021Article
- Epidemiology of hepatitis C virus infection in a tertiary care hospital.Medical journal, Armed Forces India · 2020Article
- Hepatitis B genotyping: The utility for the clinicians.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Article
- Serological markers and molecular analysis of hepatitis B infection in a tertiary care hospital at Kathmandu, Nepal.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Article
- Diversity of hepatitis C virus infection among HIV-infected people who inject drugs in India.Virusdisease · 2019Article
- Comparative Antiviral Efficacy of Generic Sofosbuvir versus Brand Name Sofosbuvir with Ribavirin for the Treatment of Hepatitis C.Interdisciplinary perspectives on infectious diseases · 2018Article
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Authors and funding
24 authors.
Funding
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Abstract
BACKGROUND AND
aimsAlthough chronic hepatitis C virus (HCV) infection affects millions of people in India, few studies have assessed host, viral, and disease characteristics of chronically infected patients at national and regional levels. Such information is critical to support large scale screening and treatment initiatives for chronic HCV infection in India.
methodsPatients with known chronic HCV infection making routine or for-cause visits to the participating study centers were enrolled in this observational study. Patients attended a single outpatient visit during which demographics and medical history were collected, a physical examination was performed, and blood and urine samples were collected for laboratory assessments. Samples were analyzed to determine HCV genotypes and subtypes, and genotypes of interferon lambda 3 (IFNL3) single nucleotide polymorphism. No therapeutic interventions were administered.
resultsWe enrolled 500 patients at 19 centers, categorized into four geographic regions (North, South, East, and West). All patients self-identified as Indian, and most (66 %) were male. Genotype 3 was the most common genotype overall (54 %); however, its prevalence varied greatly by region, ranging from 34 % in the South to 69 % in the East. Genotypes 1 (24 %) and 4 (6 %) were the next most common, and HCV genotype could not be determined for 16 % of patients.
conclusionsThis prospective survey suggests that demographics, viral, and host factors in patients with chronic HCV infection are highly variable in India and pose significant challenges for the implementation of broad-scale screening and treatment initiatives.
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