Evidence map›Paper›PMID 27844106›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2017

Lymphoma: current status of clinical and preclinical imaging with radiolabeled antibodies.

Christopher G England, Lixin Rui, Weibo Cai

Abstract readReview
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. European journal of nuclear medicine and molecular imaging · 2022
    Article
  3. Article
  4. Article
  5. Noninvasive Evaluation of CD20 Expression UsingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  6. Review
  7. Review
  8. European journal of nuclear medicine and molecular imaging · 2019
    Article
  9. HER2-targeted multimodal imaging of anaplastic thyroid cancer.American journal of cancer research · 2019
    Article
  10. PET Imaging of Receptor Tyrosine Kinases in Cancer.Molecular cancer therapeutics · 2018
    Review
  11. Evaluation of Next-Generation Anti-CD20 Antibodies Labeled withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Article
  12. Article
  13. Article
  14. PET and SPECT imaging of melanoma: the state of the art.European journal of nuclear medicine and molecular imaging · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Christopher G EnglandDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI, 53705-2275, USA. cengland2@wisc.edu.
Lixin RuiDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Weibo CaiDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI, 53705-2275, USA. wcai@uwhealth.org.
University of Wisconsin Carbone Cancer Center · USUniversity of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Membranous Nanogenerators for in vivo Bio-mechanical Energy HarvestingR01EB021336 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI WANG, XUDONG · 2016 to 2020
$1.7M
Novel Combination Therapy for Prostate CancerR01CA169365 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO · 2013 to 2015
$903k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA169365NCI NIH HHS T32 CA009206NIBIB NIH HHS R01 EB021336
6 · The paper itself

Abstract

Lymphoma is a complex disease that arises from cells of the immune system with an intricate pathology. While lymphoma may be classified as Hodgkin or non-Hodgkin, each type of tumor is genetically and phenotypically different and highly invasive tissue biopsies are the only method to investigate these differences. Noninvasive imaging strategies, such as immunoPET, can provide a vital insight into disease staging, monitoring treatment response in patients, and dose planning in radioimmunotherapy. ImmunoPET imaging with radiolabeled antibody-based tracers may also assist physicians in optimizing treatment strategies and enhancing patient stratification. Currently, there are two common biomarkers for molecular imaging of lymphoma, CD20 and CD30, both of which have been considered for investigation in preclinical imaging studies. In this review, we examine the current status of both preclinical and clinical imaging of lymphoma using radiolabeled antibodies. Additionally, we briefly investigate the role of radiolabeled antibodies in lymphoma therapy. As radiolabeled antibodies play critical roles in both imaging and therapy of lymphoma, the development of novel antibodies and the discovery of new biomarkers may greatly affect lymphoma imaging and therapy in the future.

Indexed as

Clinical Trials as TopicAnimalsAntibodies, MonoclonalHumansLymphomaPositron-Emission TomographyRadioimmunotherapyRadiopharmaceuticalsAntibodies, MonoclonalRadiopharmaceuticalsCancer imagingHodgkin lymphomaMolecular imagingNon-Hodgkin lymphomaPositron emission tomographyRadioimmunotherapy

Identifiers

PMID27844106
PMCPMC5285396
OpenAlexW2552819876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.