Evidence map›Paper›PMID 27843890›Full record

ArticleFrontiers in pediatrics2016

Predictors of Memory Deficits in Adolescents and Young Adults with Congenital Heart Disease Compared to Healthy Controls.

Nancy A Pike, Mary A Woo, Marie K Poulsen, Wendy Evangelista, Dylan Faire, Nancy J Halnon, Alan B Lewis, Rajesh Kumar

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06326996 (Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06326996 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2026Enrolled52ConditionsCoronary Heart Disease, Coronary Artery Bypass GraftingArmsThiamine, Placebo
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Extracorporeal membrane oxygenation (ECMO) in pediatric congenital heart disease: a comprehensive review.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Cardiovascular and Stroke Nursing Council Science in Review.Journal of the American Heart Association · 2019
    Article
  16. Review
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nancy A PikeSchool of Nursing, University of California Los Angeles , Los Angeles, CA , USA.
Mary A WooSchool of Nursing, University of California Los Angeles , Los Angeles, CA , USA.
Marie K PoulsenDivision of General Pediatrics, Children's Hospital Los Angeles , Los Angeles, CA , USA.
Wendy EvangelistaSchool of Nursing, University of California Los Angeles , Los Angeles, CA , USA.
Dylan FaireSchool of Nursing, University of California Los Angeles , Los Angeles, CA , USA.
Nancy J HalnonDivision of Pediatric Cardiology, University of California Los Angeles , Los Angeles, CA , USA.
Alan B LewisDivision of Pediatric Cardiology, Children's Hospital Los Angeles , Los Angeles, CA , USA.
Rajesh KumarDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, CA, USA; Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, USA; Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA; The Brain Research Institute, University of California Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · USChildren's Hospital of Los Angeles · US

Funding

Memory and Brain Structure in Adolescents with Single Ventricle Heart DiseaseR01NR013930 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIKE, NANCY ANN · 2013 to 2016
$1.4M
NINR NIH HHS R01 NR013930
6 · The paper itself

Abstract

introductionAdolescents and young adults with congenital heart disease (CHD) show a range of memory deficits, which can dramatically impact their clinical outcomes and quality of life. However, few studies have identified predictors of these memory changes. The purpose of this investigation was to identify predictors of memory deficits in adolescents and young adults with CHD after surgical palliation compared to healthy controls.

methodOne hundred fifty-six adolescents and young adults (80 CHD and 76 controls; age 14-21 years) were recruited and administered an instrument to assess memory [Wide Range Assessment of Memory and Learning Second Edition - general memory index (GMI) score] and completed questionnaires that measure anxiety, depression, sleepiness, health status, and self-efficacy. Descriptive and non-parametric statistics were used to assess group differences, and logistic regression to identify predictors of memory deficits.

resultsCHD subjects consisted of 58% males, median age 17 years, 43% Hispanic, and medians of 2 previous heart surgeries and 14 years since last surgery. Memory deficits (GMI ≤ 85) were identified in 50% CHD compared to 4% healthy controls (median GMI 85 vs. 104,

conclusionAdolescents and young adults with CHD, more than a decade since their last surgery, show significant verbal, attention, and working memory deficits over controls. To enhance patient memory/self-care, clinicians should explore ways to reduce anxiety, improve self-efficacy, and increase use of visual patient education material, especially in CHD males.

Indexed as

anxietycongenital heart diseasememoryself-efficacyworking memory

Identifiers

PMID27843890
PMCPMC5086579
OpenAlexW2543867807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.