ReviewJournal of family medicine and primary care
Impact of antiepileptic drugs on bone health: Need for monitoring, treatment, and prevention strategies.
Review in Journal of family medicine and primary care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Vitamin D content and prevalence of vitamin D deficiency in patients with epilepsy: a systematic review and meta-analysis.Frontiers in nutrition · 2024Pooled it
- A Prospective Study on the Effect of Antiseizure Medications on the Bone Mineral Density of Children with Drug-Naïve Epilepsy.Indian pediatrics · 2026Article
- Time-Dependent Effect of Anti-seizure Medications on Bone Metabolism in Patients with Epilepsy: A Cross-Sectional Study.Neurology and therapy · 2026Article
- Individuals diagnosed with epilepsy: a fractal analysis and radiomorphometric evaluation.BMC oral health · 2026Article
- Unraveling the nutritional challenges in epilepsy: Risks, deficiencies, and management strategies: A systematic review.World journal of experimental medicine · 2025Article
- Evaluation of mandibular bone quality with respect to enzyme inducement potential of antiepileptic drugs via fractal analysis.BMC oral health · 2025Article
- A rare cause for osteonecrosis of femoral head and peripheral nerve damage of a child with depression.BMC musculoskeletal disorders · 2025Article
- Vitamin D status of pediatric epilepsy patients and evaluation of affecting factors.Italian journal of pediatrics · 2025Article
- Osteoporosis diagnosis and ingredients of prescription medications: a population-based study.Frontiers in pharmacology · 2025Article
- Duration Matters: Anticonvulsant Therapy Linked to Bone Loss in Interim Cross-Sectional Study.Consortium psychiatricum · 2025Article
- Effect of Anti-Seizure Medication Monotherapy on Vitamin D Levels in Indian Children: A Longitudinal Cohort Study.Journal of epilepsy research · 2024Article
- Assessment of Bone Mineral Density Over 1 Year in a Cross-Sectional Cohort of Migraine Patients Receiving Anti-CGRP Monoclonal Antibodies.CNS drugs · 2024Article
- Hormonal Changes in Women with Epilepsy.Neuropsychiatric disease and treatment · 2024Review
- Osteomalacia in Adults: A Practical Insight for Clinicians.Journal of clinical medicine · 2023Review
- Impact of seborrheic dermatitis on osteoporosis risk: A population-based cohort study.The Journal of dermatology · 2022Article
- Review
- Bone health, intellectual disability and epilepsy: An observational community-based study.Acta neurologica Scandinavica · 2022Observational
- A Systematic Review of the Management of Upper Extremity Orthopaedic Injuries in Epileptic Patients.The archives of bone and joint surgery · 2022Review
- Article
- Bone health in adults with epilepsy and intellectual disability.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is the most common neurological disorder affecting approximately 50 million people worldwide. In India, overall prevalence of epilepsy is reported to be 5.59/1000 population. Antiepileptic drugs (AEDs) constitute the main-stay of treatment with a large number of AEDs available in the market. High incidence of adverse effects is a major limitation with AEDs. One of the major concerns is significant metabolic effects on the bone. However, little attention has been paid to this issue because most of the bone effects remain subclinical for a long time and may take years to manifest clinically. The main effects include hypocalcemia, hypophosphatemia, reduced serum levels of Vitamin D, increase in parathormone (PTH) levels, and alterations in bone turnover markers. The CYP450 enzyme-inducing AEDs such as phenytoin, phenobarbital, carbamazepine, and primidone are the most common AEDs associated with bone disorders while the data regarding the effect of valproate and newer AEDs such as lamotrigine, gabapentin, vigabatrin, levetiracetam, and topiramate on bone metabolism and bone density are scanty and controversial. Deficiency of Vitamin D is commonly described as a cause for the bone loss in epileptic patients while others being decreased absorption of calcium, increased PTH levels, and inhibition of calcitonin secretion, etc. However, there are no formal practical guidelines for the management of bone disease among those taking AEDs. Evidence-based strategies regarding monitoring, prevention, and treatment of bone diseases in patients on AED therapy are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.