ArticleEuropean thyroid journal2016
Relational Stability of Thyroid Hormones in Euthyroid Subjects and Patients with Autoimmune Thyroid Disease.
Article in European thyroid journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Endocrine-Immune Crosstalk in Pediatric Autoimmune Diseases: A Systematic Review of the Role of Micronutrients, with Emphasis on Vitamin D.Nutrients · 2026Pooled it
- Dissecting biomarker networks linking COVID-19 inflammatory drivers, disease severity and thyroid adaptive responses.Scientific reports · 2025Article
- The relationship between levothyroxine dosage and free thyroxine levels in hypothyroid patients: a large retrospective study.European thyroid journal · 2025Article
- The role of supporting and disruptive mechanisms of FT3 homeostasis in regulating the hypothalamic-pituitary-thyroid axis.Therapeutic advances in endocrinology and metabolism · 2023Article
- Principles of Endocrine Regulation: Reconciling Tensions Between Robustness in Performance and Adaptation to Change.Frontiers in endocrinology · 2022Article
- Profiling retrospective thyroid function data in complete thyroidectomy patients to investigate the HPT axis set point (PREDICT-IT).Journal of endocrinological investigation · 2021Article
- Associations Between Thyroid Hormones and Glycated Albumin in Euthyroid and Subclinical Hypothyroid Individuals: Results of an Observational Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Changes in glucose-lipid metabolism, insulin resistance, and inflammatory factors in patients with autoimmune thyroid disease.Journal of clinical laboratory analysis · 2019Article
- Time for a reassessment of the treatment of hypothyroidism.BMC endocrine disorders · 2019Article
- Individualised requirements for optimum treatment of hypothyroidism: complex needs, limited options.Drugs in context · 2019Review
- Functional and Symptomatic Individuality in the Response to Levothyroxine Treatment.Frontiers in endocrinology · 2019Article
- Editorial: "Homeostasis and Allostasis of Thyroid Function".Frontiers in endocrinology · 2018Article
- Dual control of pituitary thyroid stimulating hormone secretion by thyroxine and triiodothyronine in athyreotic patients.Therapeutic advances in endocrinology and metabolism · 2017Article
- Hippocampal Administration of Levothyroxine Impairs Contextual Fear Memory Consolidation in Rats.Frontiers in cellular neuroscience · 2017Article
- Advances in applied homeostatic modelling of the relationship between thyrotropin and free thyroxine.PloS one · 2017Article
- Recent Advances in Thyroid Hormone Regulation: Toward a New Paradigm for Optimal Diagnosis and Treatment.Frontiers in endocrinology · 2017Review
- Thyroid Allostasis-Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming.Frontiers in endocrinology · 2017Review
- Relational Stability in the Expression of Normality, Variation, and Control of Thyroid Function.Frontiers in endocrinology · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimOperating far from its equilibrium resting point, the thyroid gland requires stimulation via feedback-controlled pituitary thyrotropin (TSH) secretion to maintain adequate hormone supply. We explored and defined variations in the expression of control mechanisms and physiological responses across the euthyroid reference range.
methodsWe analyzed the relational equilibria between thyroid parameters defining thyroid production and thyroid conversion in a group of 271 thyroid-healthy subjects and 86 untreated patients with thyroid autoimmune disease.
resultsIn the euthyroid controls, the FT
conclusionThe euthyroid panel does not follow a homogeneous pattern to produce random variation among thyroid hormones and TSH, but forms a heterogeneous group that progressively displays distinctly different levels of homeostatic control across the euthyroid range. This suggests a concept of relational stability with implications for definition of euthyroidism and disease classification.
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