Evidence map›Paper›PMID 27843750›Full record

ArticleSpringerPlus2016

Permeability and distribution of nerve growth factor in the brain of neonatal rats by periphery venous injection in hypoxic-ischemic state.

Wenli Zhou, Jiantao Zhang, Guangming Wang, Limian Ling, Chaoying Yan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SpringerPlus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wenli Zhou *Department of Neonatology, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021 Jilin China.
Jiantao Zhang *Department of Colorectal and Anal Surgery, The First Hospital of Jilin University, Changchun, 130021 Jilin China.
Guangming WangDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021 Jilin China.
Limian LingDepartment of Colorectal and Anal Surgery, The First Hospital of Jilin University, Changchun, 130021 Jilin China.
Chaoying YanDepartment of Neonatology, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021 Jilin China.
Jilin University · CNFirst Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the permeability of β-NGF through blood-brain-barrier (BBB) in neonatal and adult rats, and the spatial distribution of β-NGF in different brain regions in hypoxic-ischemic (HI) and normal neonatal rats.

methodsTo investigate the overall permeability of β-NGF through BBB, β-NGF labeled with I

resultsStatistically significant results were observed in I

conclusionβ-NGF can more easily penetrate the BBB of newborn rats than adult rats via peripheral venous administration and this effect can be enhanced by HI insult. Also, this HI-induced permeation of β-NGF through BBB is more obvious in frontal cortex, hippocampus and cerebellum.

Indexed as

Blood–brain barrierHypoxicIschemicNerve growth factor

Identifiers

PMID27843750
PMCPMC5084138
OpenAlexW2540630040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.